CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010640
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydropyrimidinase-related protein 1 
Protein Synonyms/Alias
 DRP-1; Collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3; ULIP-3 
Gene Name
 Crmp1 
Gene Synonyms/Alias
 Dpysl1; Ulip3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MSHQGKKSIPHITSubiquitination[1]
56LIVPGGVKTIEANGRubiquitination[1]
293DGTHYWSKNWAKAAAubiquitination[1]
463DGNISVSKGMGRFIPubiquitination[1]
472MGRFIPRKPFPEHLYubiquitination[1]
487QRVRIRSKVFGLHSVubiquitination[1]
511YEVPATPKHAAPAPSubiquitination[1]
520AAPAPSAKSSPSKHQubiquitination[1]
525SAKSSPSKHQPPPIRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. 
Sequence Annotation
 MOD_RES 316 316 Nitrated tyrosine.
 MOD_RES 431 431 Phosphotyrosine.
 MOD_RES 504 504 Phosphotyrosine.
 MOD_RES 509 509 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nitration; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MSHQGKKSIP HITSDRLLIR GGRIINDDQS FYADVYLEDG LIKQIGENLI VPGGVKTIEA 60
NGRMVIPGGI DVNTYLQKPS QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGSSLLTSF 120
EKWHEAADTK SCCDYSLHVD ITSWYDGVRE ELEVLVQDKG VNSFQVYMAY KDLYQMSDSQ 180
LYEAFTFLKG LGAVILVHAE NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI 240
AIAGRINCPV YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA 300
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL IPEGVNGIEE 360
RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR IAVGSDADVV IWDPDKMKTI 420
TAKSHKSTVE YNIFEGMECH GSPLVVISQG KIVFEDGNIS VSKGMGRFIP RKPFPEHLYQ 480
RVRIRSKVFG LHSVSRGMYD GPVYEVPATP KHAAPAPSAK SSPSKHQPPP IRNLHQSNFS 540
LSGAQIDDNN PRRTGHRIVA PPGGRSNITS LG 572 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro. 
Interpro
 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS