CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023166
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATPase family AAA domain-containing protein 2B 
Protein Synonyms/Alias
  
Gene Name
 ATAD2B 
Gene Synonyms/Alias
 KIAA1240 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
447YGPPGTGKTLVARALubiquitination[1]
604FLGELAEKCVGYCGAubiquitination[2]
810ALYSVSAKTPEESCAubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 975 1045 Bromo.
 NP_BIND 441 448 ATP (Potential).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 1338 1338 Phosphoserine.
 MOD_RES 1347 1347 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Bromodomain; Coiled coil; Complete proteome; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1458 AA 
Protein Sequence
MVNTRKSSLR LLGSKSPGPG PGPGAGAEPG ATGGSSHFIS SRTRSSKTRA ASCPAAKAGG 60
SGGAGVTLDE ARKVEVDGSL SDSHVSPPAK RTLKQPDSVC KDKSKSRSTG QREEWNLSTG 120
QARLTSQPGA TLPNGHSGLS LRSHPLRGEK KGDGDLSCIN GDMEVRKSCR SRKNRFESVN 180
QSLLFDQLVN STAEAVLQEM DNINIRQNRR SGEVERLRMW TDTEFENMDM YSRVKRRRKS 240
LRRNSYGIQN HHEVSTEGEE EESQEEDGDI EVEEAEGEEN DRPYNLRQRK TVDRYQAPPI 300
VPAHQKKREN TLFDIHRSPA RRSHIRRKKH AIHSSDTTSS DEERFERRKS KSMARARNRC 360
LPMNFRAEDL ASGILRERVK VGASLADVDP MNIDKSVRFD SIGGLSHHIH ALKEMVVFPL 420
LYPEIFEKFK IQPPRGCLFY GPPGTGKTLV ARALANECSQ GDKKVAFFMR KGADCLSKWV 480
GESERQLRLL FDQAYLMRPS IIFFDEIDGL APVRSSRQDQ IHSSIVSTLL ALMDGLDNRG 540
EIVVIGATNR LDSIDPALRR PGRFDREFLF NLPDQKARKH ILQIHTRDWN PKLSDAFLGE 600
LAEKCVGYCG ADIKALCTEA ALIALRRRYP QIYASSHKLQ LDVSSIVLSA QDFYHAMQNI 660
VPASQRAVMS SGHALSPIIR PLLERSFNNI LAVLQKVFPH AEISQSDKKE DIETLILEDS 720
EDENALSIFE TNCHSGSPKK QSSSAAIHKP YLHFTMSPYH QPTSYRPRLL LSGERGSGQT 780
SHLAPALLHT LERFSVHRLD LPALYSVSAK TPEESCAQIF REARRTVPSI VYMPHIGDWW 840
EAVSETVRAT FLTLLQDIPS FSPIFLLSTS ETMYSELPEE VKCIFRIQYE EVLYIQRPIE 900
EDRRKFFQEL ILNQASMAPP RRKHAALCAM EVLPLALPSP PRQLSESEKS RMEDQEENTL 960
RELRLFLRDV TKRLATDKRF NIFSKPVDIE EVSDYLEVIK EPMDLSTVIT KIDKHNYLTA 1020
KDFLKDIDLI CSNALEYNPD KDPGDKIIRH RACTLKDTAH AIIAAELDPE FNKLCEEIKE 1080
ARIKRGLSVT SEQINPHSTG ARKTETRVEE AFRHKQRNPM DVWHNSANKC AFRVRRKSRR 1140
RSQWGKGIIK KRKVNNLKKD EEDTKFADYE NHTEDRKLLE NGEFEVSTDC HEENGEETGD 1200
LSMTNDESSC DIMDLDQGQR LNNGAGTKEN FASTEEESSN ESLLVNSSSS LNPEQTSRKE 1260
TFLKGNCLNG EASTDSFEGI PVLECQNGKL EVVSFCDSGD KCSSEQKILL EDQSKEKPET 1320
STENHGDDLE KLEALECSNN EKLEPGSDVE VKDAELDKEG ASKVKKYRKL ILEQAKTTSL 1380
ELVPEEPSEP VPPLIVDRER LKKLLDLLVD KSNNLAVDQL ERLYSLLSQC IYRHRKDYDK 1440
SQLVEEMERT VHMFETFL 1458 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0070577; F:histone acetyl-lysine binding; IDA:UniProtKB.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA
 PF00439; Bromodomain 
SMART
 SM00382; AAA
 SM00297; BROMO 
PROSITE
 PS00674; AAA
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2 
PRINTS
 PR00503; BROMODOMAIN.