| Tag | Content |
|---|
| CPLM ID | CPLM-012811 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | V-type proton ATPase 116 kDa subunit a isoform 1 |
Protein Synonyms/Alias | V-ATPase 116 kDa isoform a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
Gene Name | ATP6V0A1 |
Gene Synonyms/Alias | ATP6N1; VPP1 |
Created Date | July 27, 2013 |
Organism | Bos taurus (Bovine) |
NCBI Taxa ID | 9913 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 667 | RRQYLRRKHLGTLNF | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). |
Sequence Annotation | MOD_RES 250 250 Phosphothreonine (By similarity).
MOD_RES 364 364 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Hydrogen ion transport; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 838 AA |
Protein Sequence | MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE 60
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR 120
NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPSEM GRGTPLRLGF VAGVINRERI 180
PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF 240
RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM 300
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT 360
PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDL GHGILMTLFA 420
VWMVLKESRI LSQKNENEMF STIFSGRYII LLMGVFSIYT GLIYNDCFSK SLNIFGSSWS 480
VRPMFDIYNW TEETLRGNPV LQLNPAVTGV FGGPYPFGID PIWNIATNKL TFLNSFKMKM 540
SVILGIIHML FGVSLSLFNH TYFKKPLNIY FGFIPEIIFM TSLFGYLVIL IFYKWTAYNA 600
KTSEKAPSLL IHFINMFLFS YGDSGNSMLY SGQKGIQCFL VVVALLCVPW MLLFKPLVLR 660
RQYLRRKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEPTEDE VFDFGDTMVH 720
QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHIGLKVKSL AGGLALFFIF 780
AAFATLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYSGTG FKFLPFSFEH IREGKFDD 838 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro. GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro. GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |