| Tag | Content |
|---|
| CPLM ID | CPLM-004234 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle 54 kDa protein |
Protein Synonyms/Alias | SRP54 |
Gene Name | Srp54 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | DVNIKLVKQLRENVK | ubiquitination | [1] | | 71 | EMASGLNKRKMIQHA | ubiquitination | [1] | | 311 | IDKVNELKLDDNEAL | ubiquitination | [1] | | 321 | DNEALIEKLKHGQFT | ubiquitination | [1] | | 323 | EALIEKLKHGQFTLR | ubiquitination | [1] | | 374 | ESMARLKKLMTIMDS | ubiquitination | [1] | | 426 | ELLTQYTKFAQMVKK | ubiquitination | [1] | | 448 | FKGGDMSKNVSQSQM | ubiquitination | [1] | | 457 | VSQSQMAKLNQQMAK | ubiquitination | [1] | | 464 | KLNQQMAKMMDPRVL | ubiquitination | [1] | | 496 | QGAAGNMKGMMGFNN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). |
Sequence Annotation | NP_BIND 108 115 GTP (By similarity).
NP_BIND 190 194 GTP (By similarity).
NP_BIND 248 251 GTP (By similarity).
REGION 1 295 G-domain.
REGION 296 504 M-domain. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK QLRENVKSAI 60
DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK QNVIMFVGLQ GSGKTTTCSK 120
LAYYYQRKGW KTCLICADTF RAGAFDQLKQ NATKARIPFY GSYTEMDPVI IASEGVEKFK 180
NENFEIIIVD TSGRHKQEDS LFEEMLQVSN AIQPDNIVYV MDASIGQACE AQAKAFKDKV 240
DVASVIVTKL DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI 300
EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG MIPGFGTDFM 360
SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP GRIQRVARGS GVSTRDVQEL 420
LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL 480
QSMMRQFQQG AAGNMKGMMG FNNM 504 |
Gene Ontology | GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW. GO:0008312; F:7S RNA binding; IEA:InterPro. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0006184; P:GTP catabolic process; IEA:GOC. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |