UniProt Accession

 FXYD5_HUMAN; Q96DB9; B7WNZ8; Q6UW44; Q9HC34; Q9P039 

Genbank Protein ID

 AF177940; AB072911; AF161462; AY358991; BT007343; AC002390; AC020907; BC009642 

Genbank Nucleotide ID

 AAG09301.1; BAB83766.1; AAF29077.1; AAQ89350.1; AAP36007.1; AAH09642.1 

Protein Name

 FXYD domain-containing ion transport regulator 5 

Protein Synonyms/Alias

 Dysadherin 

Gene Name

 FXYD5 

Gene Synonyms/Alias

 DYSAD; IWU1; HSPC113; UNQ2561/PRO6241 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	PTRGQTLKDTTSSSS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. 

Sequence Annotation

 MOD_RES 112 112 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0003779; F:actin binding; IDA:UniProtKB.
 GO:0045296; F:cadherin binding; IDA:UniProtKB.
 GO:0005216; F:ion channel activity; IEA:InterPro.
 GO:0030033; P:microvillus assembly; NAS:UniProtKB.
 GO:0046588; P:negative regulation of calcium-dependent cell-cell adhesion; NAS:UniProtKB. 

Interpro

 IPR000272; Ion-transport_regulator_FXYD. 

Pfam

 PF02038; ATP1G1_PLM_MAT8 

SMART

  

PROSITE

 PS01310; FXYD 

PRINTS