UniProt Accession

 NFIC_MOUSE; P70255; O09072; P70256; Q3U2I9; Q99MA3; Q99MA4; Q99MA5; Q99MA6; Q99MA7; Q99MA8; Q9R1G3 

Genbank Protein ID

 Y07692; Y07693; U57635; AK087539; AK155258; AF358455; AF358456; AF358457; AF358458; AF358459; AF358460; AF111265 

Genbank Nucleotide ID

 CAA68956.1; CAA68957.1; AAB49930.1; BAC39918.1; BAE33151.1; AAK21331.1; AAK21332.1; AAK21333.1; AAK21334.1; AAK21335.1; AAK21336.1; AAD39100.1 

Protein Name

 Nuclear factor 1 C-type 

Protein Synonyms/Alias

 NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein 

Gene Name

 Nfic 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	KDEERAVKDELLGEK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. 

Sequence Annotation

 DNA_BIND 1 195 CTF/NF-I.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 194 194 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 323 323 Phosphoserine (By similarity).
 MOD_RES 333 333 Phosphoserine.
 MOD_RES 337 337 Phosphoserine.
 MOD_RES 339 339 Phosphoserine.
 MOD_RES 343 343 Phosphoserine.
 MOD_RES 378 378 Phosphothreonine.  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; DNA replication; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 439 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000647; CTF/NFI.
 IPR020604; CTF/NFI_DNA-bd-dom.
 IPR019739; CTF/NFI_DNA-bd_CS.
 IPR019548; CTF/NFI_DNA-bd_N.
 IPR003619; MAD_homology1_Dwarfin-type. 

Pfam

 PF00859; CTF_NFI
 PF03165; MH1
 PF10524; NfI_DNAbd_pre-N 

SMART

 SM00523; DWA 

PROSITE

 PS00349; CTF_NFI_1
 PS51080; CTF_NFI_2 

PRINTS