UniProt Accession

 LAM0_DROME; P08928; Q9VMQ0 

Genbank Protein ID

 X07278; X16275; AE014134; BT001506 

Genbank Nucleotide ID

 CAA30259.1; CAA34351.1; AAF52262.1; AAN71261.1 

Protein Name

 Lamin Dm0 

Protein Synonyms/Alias

  

Gene Name

 Lam 

Gene Synonyms/Alias

 CG6944 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
55	RHSRVAEKVELQNLN	acetylation	[1]
170	RANELNNKYNQANAD	acetylation	[1]
293	IQSLYEDKIQRLQEA	acetylation	[1]
310	RTSNSTHKSIEELRS	acetylation	[1]
476	AKGNVEIKEIDPEGK	acetylation	[1]
483	KEIDPEGKFVRLFNK	acetylation	[1]
509	LQRLINEKGPSTTYK	acetylation	[1]
516	KGPSTTYKFHRSVRI	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. 

Sequence Annotation

 REGION 2 56 Head.
 REGION 55 91 Coil 1A.
 REGION 57 408 Rod.
 REGION 92 103 Linker 1.
 REGION 104 241 Coil 1B.
 REGION 242 265 Linker 2.
 REGION 266 408 Coil 2.
 REGION 409 619 Tail.
 MOTIF 446 451 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 10 10 Phosphothreonine.
 MOD_RES 12 12 Phosphothreonine.
 MOD_RES 20 20 Phosphothreonine.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 39 39 Phosphothreonine.
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 47 47 Phosphothreonine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 249 249 Phosphotyrosine.
 MOD_RES 250 250 Phosphoserine.
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 413 413 Phosphothreonine.
 MOD_RES 435 435 Phosphothreonine.
 MOD_RES 442 442 Phosphoserine.
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 459 459 Phosphoserine.
 MOD_RES 595 595 Phosphoserine.
 MOD_RES 597 597 Phosphothreonine.
 MOD_RES 615 615 Phosphoserine.
 MOD_RES 619 619 Cysteine methyl ester (By similarity).
 LIPID 619 619 S-farnesyl cysteine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Intermediate filament; Lipoprotein; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 622 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:FlyBase.
 GO:0005638; C:lamin filament; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0072686; C:mitotic spindle; IDA:FlyBase.
 GO:0005635; C:nuclear envelope; IDA:FlyBase.
 GO:0005198; F:structural molecule activity; IMP:FlyBase.
 GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
 GO:0007569; P:cell aging; IMP:FlyBase.
 GO:0007417; P:central nervous system development; IMP:FlyBase.
 GO:0051297; P:centrosome organization; IMP:FlyBase.
 GO:0040003; P:chitin-based cuticle development; IMP:FlyBase.
 GO:0006342; P:chromatin silencing; IDA:FlyBase.
 GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
 GO:0048546; P:digestive tract morphogenesis; IMP:FlyBase.
 GO:0035262; P:gonad morphogenesis; IMP:FlyBase.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0007084; P:mitotic nuclear envelope reassembly; IDA:FlyBase.
 GO:0071763; P:nuclear membrane organization; IDA:FlyBase.
 GO:0007097; P:nuclear migration; IMP:FlyBase.
 GO:0031081; P:nuclear pore distribution; IMP:FlyBase.
 GO:0090435; P:protein localization to nuclear envelope; IMP:FlyBase.
 GO:0007430; P:terminal branching, open tracheal system; IMP:FlyBase. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR001322; Lamin_tail_dom. 

Pfam

 PF00038; Filament
 PF00932; LTD 

SMART

  

PROSITE

 PS00226; IF 

PRINTS