Tag | Content |
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CPLM ID | CPLM-014048 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent RNA helicase DDX39A |
Protein Synonyms/Alias | DEAD box protein 39; Nuclear RNA helicase, DECD variant of DEAD box family |
Gene Name | Ddx39a |
Gene Synonyms/Alias | Ddx39; Ddxl |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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35 | APPKKDVKGSYVSIH | acetylation | [1] | 52 | GFRDFLLKPELLRAI | acetylation | [1] | 137 | KEYERFSKYMPSVKV | acetylation | [1] | 267 | GLQQYYVKLKDSEKN | acetylation | [1] | 333 | LSRYQQFKDFQRRIL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). |
Sequence Annotation | DOMAIN 75 248 Helicase ATP-binding. DOMAIN 260 421 Helicase C-terminal. NP_BIND 88 95 ATP (By similarity). MOTIF 44 72 Q motif. MOTIF 195 198 DECD box. MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 35 35 N6-acetyllysine (By similarity). MOD_RES 171 171 Phosphothreonine (By similarity). MOD_RES 426 426 Phosphoserine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 427 AA |
Protein Sequence | MAEQDVENEL LDYDEDEEPQ VPQESTPAPP KKDVKGSYVS IHSSGFRDFL LKPELLRAIV 60 DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL ATLQQIEPIN GQVSVLVMCH 120 TRELAFQISK EYERFSKYMP SVKVSVFFGG LSIKKDEDVL KKNCPHVVVG TPGRILALVR 180 SRSLNLRNVK HFVLDECDKM LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKEIRPVCRK 240 FMQDPMEVFV DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVV IFVKSVQRCM 300 ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM DIERVNIVFN 360 YDMPEDSDTY LHRVARAGRF GTKGLAVTFV SDENDAKILN DVQDRFEVNV AELPEEIDIS 420 TYIEQSR 427 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0006406; P:mRNA export from nucleus; IEA:Compara. GO:0000398; P:mRNA splicing, via spliceosome; IEA:Compara. |
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PRINTS | |