UniProt Accession

 PPIE_HUMAN; Q9UNP9; B2R971; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5 

Genbank Protein ID

 AF104012; AF104013; AF042385; AF042386; DQ160195; AK313666; AL049824; AL033527; AL035404; AL049824; AL033527; AL035404; AL049824; AL035404; AL033527; AL035404; AL049824; AL033527; AL035404; AL049824; AL035404; AL033527; AL049824; AL035404; AL033527; AL049824; AL035404; AL049824; CH471059; BC004898; BC008451; BC107736 

Genbank Nucleotide ID

 AAD19906.1; AAD19907.1; AAC00006.1; AAC00007.1; AAZ93379.1; BAG36418.1; CAI19347.1; CAI19347.1; CAI19347.1; CAI19348.1; CAI19348.1; CAI19348.1; CAI19350.1; CAI19350.1; CAI19409.1; CAI19409.1; CAI19409.1; CAI19410.1; CAI19410.1; CAI19410.1; CAI19576.1; CAI19576.1; CAI19576.1; CAI19577.1; CAI19577.1; CAI19577.1; CAI19579.1; CAI19579.1; EAX07255.1; AAH04898.1; AAH08451.1; AAI07737.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase E 

Protein Synonyms/Alias

 PPIase E; Cyclophilin E; Cyclophilin-33; Rotamase E 

Gene Name

 PPIE 

Gene Synonyms/Alias

 CYP33 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	TIRVNLAKPMRIKEG	ubiquitination	[1]
218	GKSIYGKKFDDENFI	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing. 

Sequence Annotation

 DOMAIN 6 84 RRM.
 DOMAIN 143 299 PPIase cyclophilin-type.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Isomerase; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding; Rotamase; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0016018; F:cyclosporin A binding; TAS:ProtInc.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; TAS:UniProtKB.
 GO:0003723; F:RNA binding; TAS:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0045070; P:positive regulation of viral genome replication; IMP:UniProtKB.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:UniProtKB. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR016304; Cyclophilin-type_PPIase_E.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00160; Pro_isomerase
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS50102; RRM 

PRINTS

 PR00153; CSAPPISMRASE.