UniProt Accession

 CRBB1_HUMAN; P53674 

Genbank Protein ID

 U35340; CR456425; Z95115; BC036790; X86398 

Genbank Nucleotide ID

 AAC50383.1; CAG30311.1; CAB08268.1; AAH36790.1; CAA60150.1 

Protein Name

 Beta-crystallin B1 

Protein Synonyms/Alias

 Beta-B1 crystallin 

Gene Name

 CRYBB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MSQAAKASASATV	acetylation	[1]
160	LFEGANFKGNTIEIQ	acetylation	[1]
235	SLRRLRDKQWHLEGS	methylation	[1, 2]

Reference

 [1] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 59 98 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 99 143 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 149 190 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 191 233 Beta/gamma crystallin 'Greek key' 4.
 REGION 2 58 N-terminal arm.
 REGION 144 148 Connecting peptide.
 REGION 235 252 C-terminal arm.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Cataract; Complete proteome; Direct protein sequencing; Disease mutation; Eye lens protein; Oxidation; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.