UniProt Accession

 RNF41_HUMAN; Q9H4P4; A6NFW0; B2RBT8; O75598 

Genbank Protein ID

 AF077599; AK314811; AC073896; CH471054; CH471054; BC024284; BC032637; AY007109 

Genbank Nucleotide ID

 AAC27647.1; BAG37335.1; EAW96909.1; EAW96910.1; AAH32637.1; AAG01988.1 

Protein Name

 E3 ubiquitin-protein ligase NRDP1 

Protein Synonyms/Alias

 RING finger protein 41 

Gene Name

 RNF41 

Gene Synonyms/Alias

 FLRF; NRDP1; SBBI03 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
174	KRDIQLLKAYMRAIR	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. 

Sequence Annotation

 ZN_FING 18 57 RING-type; degenerate.
 ZN_FING 78 138 SIAH-type; degenerate.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Ligase; Metal-binding; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031386; F:protein tag; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
 GO:0045619; P:regulation of lymphocyte differentiation; IEA:Compara.
 GO:0043408; P:regulation of MAPK cascade; IDA:MGI.
 GO:0045637; P:regulation of myeloid cell differentiation; IEA:Compara.
 GO:0051896; P:regulation of protein kinase B signaling cascade; IDA:MGI.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IMP:UniProtKB. 

Interpro

 IPR013323; SIAH-type.
 IPR008974; TRAF-like.
 IPR015036; USP8_interacting.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS.
 IPR013010; Znf_SIAH. 

Pfam

 PF08941; USP8_interact 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2
 PS51081; ZF_SIAH 

PRINTS