UniProt Accession

 ABCF1_HUMAN; Q8NE71; A2BF75; O14897; Q69YP6 

Genbank Protein ID

 AF027302; BA000025; AB088096; AL662800; AL662800; AL662825; AL662825; BX000357; BX000357; BX119957; BX248518; BX248518; BX119957; CR753328; CR388372; CR388372; CR753328; BX927220; CR759778; CR847863; CR847863; CR759778; BC034488; BC112923; AL832430 

Genbank Nucleotide ID

 AAC70891.1; BAB63325.1; BAC54928.1; CAI18158.1; CAI18159.1; CAI17836.1; CAI17837.1; CAI18562.1; CAI18563.1; CAM25907.1; CAM25907.1; CAM26017.1; CAM26017.1; CAQ07804.1; CAQ07804.1; CAQ07873.1; CAQ07873.1; CAQ09058.1; CAQ09401.1; CAQ09401.1; CAQ10059.1; CAQ10059.1; AAH34488.1; AAI12924.1; CAH10648.1 

Protein Name

 ATP-binding cassette sub-family F member 1 

Protein Synonyms/Alias

 ATP-binding cassette 50; TNF-alpha-stimulated ABC protein 

Gene Name

 ABCF1 

Gene Synonyms/Alias

 ABC50 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	KKDKKIKKTFFEELA	ubiquitination	[1, 2]
275	ERQVASLKAANAAEN	ubiquitination	[3]
430	GAAAAEAKARRILAG	ubiquitination	[4]
451	MQNRPTQKFSGGWRM	ubiquitination	[1, 2]
573	KSTKQAEKQTKEALT	ubiquitination	[2, 5]
582	TKEALTRKQQKCRRK	ubiquitination	[2, 5]
689	MRKNHRLKIGFFNQQ	ubiquitination	[1, 2, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265] 

Functional Description

 Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. 

Sequence Annotation

 DOMAIN 304 548 ABC transporter 1.
 DOMAIN 625 840 ABC transporter 2.
 NP_BIND 336 343 ATP 1 (By similarity).
 NP_BIND 658 665 ATP 2 (By similarity).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 108 108 Phosphothreonine.
 MOD_RES 109 109 Phosphoserine; by CK2.
 MOD_RES 140 140 Phosphoserine; by CK2.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 228 228 Phosphoserine.
 MOD_RES 595 595 Phosphoserine.
 CROSSLNK 573 573 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 582 582 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 845 AA 

Protein Sequence

Gene Ontology

 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0042788; C:polysomal ribosome; IDA:UniProtKB.
 GO:0005840; C:ribosome; IEA:Compara.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0043022; F:ribosome binding; IDA:UniProtKB.
 GO:0008494; F:translation activator activity; IDA:UniProtKB.
 GO:0008135; F:translation factor activity, nucleic acid binding; TAS:ProtInc.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0006413; P:translational initiation; IMP:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00005; ABC_tran 

SMART

 SM00382; AAA 

PROSITE

 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 

PRINTS