CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA wybutosine-synthesizing protein 3 homolog 
Protein Synonyms/Alias
 tRNA-yW-synthesizing protein 3 
Gene Name
 TYW3 
Gene Synonyms/Alias
 C1orf171 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
11SAEFRKWKAQCLSKAubiquitination[1]
17WKAQCLSKADLSRKGubiquitination[1]
23SKADLSRKGSVDEDVubiquitination[1]
99ANGDATLKFEPFVLHubiquitination[1]
136NSGITVGKRGKTMLAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). 
Sequence Annotation
 MOD_RES 25 25 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MDRSAEFRKW KAQCLSKADL SRKGSVDEDV VELVQFLNMR DQFFTTSSCA GRILLLDRGI 60
NGFEVQKQNC CWLLVTHKLC VKDDVIVALK KANGDATLKF EPFVLHVQCR QLQDAQILHS 120
MAIDSGFRNS GITVGKRGKT MLAVRSTHGL EVPLSHKGKL MVTEEYIDFL LNVANQKMEE 180
NKKRIERFYN CLQHALERET MTNLHPKIKE KNNSSYIHKK KRNPEKTRAQ CITKESDEEL 240
ENDDDDDLGI NVTIFPEDY 259 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR003827; tRNA_yW-synthesising. 
Pfam
 PF02676; TYW3 
SMART
  
PROSITE
  
PRINTS