CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027378
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone acetyltransferase GCN5, putative 
Protein Synonyms/Alias
  
Gene Name
 gcn5 
Gene Synonyms/Alias
 PF08_0034 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
637NNEFENIKRVHSNSSacetylation[1]
709STNFVNGKYISKLNNacetylation[1]
1317IKPQVIYKGINYFADacetylation[1]
1344GLLEVGWKKETREITacetylation[1]
1345LLEVGWKKETREITKacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1465 AA 
Protein Sequence
MDYLIRNNEY CNVLYDGNEL LRKRKINFDN EICPYKMNYW NNYNNNINID NDNMNNEIVN 60
EEFENTYNNI NNNMYYLLGK EDMDEPRLCN KKRNVYNENF KNNLEYDENV NNYDNDNSSN 120
ISYKFINNEC DKMKKSGEGT QENNDNENNN NDESNNNNNN NNNESNNNNN NNESNNNNNN 180
NNNNESNNNN NNNESNNNNH GNNNNSSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 240
DKNEDDENTT GKGKKTEVKK RAGRKRNDST MYANSNTMLK NNFLQNNKMI YNNMDHINDT 300
NEQDKFLYEQ RKMMMNNKME NMGPNMNMTN KNYFQTVNNM KMNVENNKNL IGINTNNMNN 360
YQNNINSINT NMNIPKNKNL HSNKQMMFMN NNMNIHGKTN KLNDMARMNS INFNEENKMS 420
VMNDDTRMDN KMRDIMKSGG MEVHLKNEES LYMNNMYNMN SNNPNNIPRI STMNIAKPMN 480
NFNNMNMPIN NMNAYNNHMI NSYNNMMMTN NMNNINNINN INHINNNNNS NNNNNSNNSN 540
NNINFGQHIQ GVQFMNPNMN NDMNSNMNNI NNNQMFLNNN QNNAHVHMVN NMNLNPSGNN 600
SFFNNSNKHL NMMTMSSKNK KNAILKNTEN NEFENIKRVH SNSSNYNNNN NNNSDSNNKK 660
SIKMNSNENN NTTTTIIKNI RVENIKFNES VNLKNIDGLD LSTNFVNGKY ISKLNNDEKI 720
YNVVHSIVKD SLKDCLVDFY NNANYIFKDK LDFVCNSNTP TCNNINDLED NKKDDGHVDK 780
QNYSLEKKDN EEHTNNNSDP IMDGVELDVK KISEKKEDQI EKDKPKNDNT KNDNTKEDKN 840
QNDDNKTNTS IPKTPKNEVK NVITSSLLSS FNIFSAFSNS NTPNSKKNKY DEEEEKEEKE 900
EEEENNKCND KDDEDKNKSP QNEDNKNITN DNNDNNNNNV DKENNLKESI DNLGNVDTDN 960
NIKRDVLNYN NIEENEQSRE YILIEITKSI CSIINLQQLM PVNTRLANPN LIYDPNYETI 1020
YSKWKTFLRK EQSSGNLISN CFSRDFLHTI LLCNYVTIIE DLRKTAVKKK LKYFFLHLCL 1080
ESGISINVAL MLFINATKQS DKLQSLLPSE TGLGYLHRDA GGAKEENMGI ITFECITNDR 1140
EPDHLIKLIT LKNIFSRQLP KMPREYIVRL VFDRNHYTFC LLKKNTVIGG VCFRPYFEQK 1200
FAEIAFLAVT STEQVKGYGT RLMNHLKEHV KKFGIEYFLT YADNFAIGYF RKQGFSQKIS 1260
MPKERWFGYI KDYDGGTLME CYIFPNINYL RLSEMLYEQK KAVKKAIHFI KPQVIYKGIN 1320
YFADNKGAAL HPSTIPGLLE VGWKKETREI TKKVQHKEVQ LKDQILGVLD YLEKQQSAWP 1380
FLKPVSLSEA PDYYDIIKEP TDILTMRRKA RHGDYKTKED FGIELKRMFD NCRLYNAPTT 1440
IYFKYANELQ TLIWPKYEAI TDTAK 1465 
Gene Ontology
 GO:0004402; F:histone acetyltransferase activity; ISS:GeneDB_Pfalciparum.
 GO:0006355; P:regulation of transcription, DNA-dependent; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR001487; Bromodomain.
 IPR000182; GNAT_dom. 
Pfam
 PF00583; Acetyltransf_1
 PF00439; Bromodomain 
SMART
 SM00297; BROMO 
PROSITE
 PS50014; BROMODOMAIN_2
 PS51186; GNAT 
PRINTS
 PR00503; BROMODOMAIN.