UniProt Accession

 AAGAB_HUMAN; Q6PD74; Q6FI86; Q7Z5X9; Q9H0P1; Q9HAK0 

Genbank Protein ID

 AK021568; AL136715; CR533540; BC001975; BC047026; BC058886 

Genbank Nucleotide ID

 BAB13845.1; CAB66649.1; CAG38571.1; AAH01975.1; AAH47026.1; AAH58886.1 

Protein Name

 Alpha- and gamma-adaptin-binding protein p34 

Protein Synonyms/Alias

  

Gene Name

 AAGAB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	EDGINRQKAQEWCIK	ubiquitination	[1]
160	FPESTGVKRIVQALN	ubiquitination	[2, 3]
177	VWSNVVMKNDRNQGF	ubiquitination	[1]
275	KLKEMKDKAATLPHE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 May be involved in endocytic recycling of growth factor receptors such as EGFR. 

Sequence Annotation

 MOD_RES 310 310 Phosphoserine.
 MOD_RES 311 311 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR019341; Alpha/Gamma-adaptin-bd_p34. 

Pfam

 PF10199; Adaptin_binding 

SMART

  

PROSITE

  

PRINTS