CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 84 
Protein Synonyms/Alias
 Zinc finger protein HPF2 
Gene Name
 ZNF84 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
125MNFVPLRKSNSEGDLubiquitination[1]
205HRNRLGEKLYECSECubiquitination[1]
275CGKAFSQKSQLTSHQubiquitination[1]
303CGKAFSRKSHLISHWubiquitination[1]
317WRTHTGEKPYGCNECubiquitination[1]
331CGRAFSEKSNLINHQubiquitination[1]
387CRKAFFEKSELIRHQubiquitination[1, 2, 3, 4]
485QRTHTGEKPYECSECubiquitination[1]
555CGKAFGEKSSLATHQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 79 KRAB.
 ZN_FING 207 229 C2H2-type 1.
 ZN_FING 235 257 C2H2-type 2.
 ZN_FING 263 285 C2H2-type 3.
 ZN_FING 291 313 C2H2-type 4.
 ZN_FING 319 341 C2H2-type 5.
 ZN_FING 347 369 C2H2-type 6.
 ZN_FING 375 397 C2H2-type 7.
 ZN_FING 403 425 C2H2-type 8.
 ZN_FING 431 453 C2H2-type 9.
 ZN_FING 459 481 C2H2-type 10.
 ZN_FING 487 509 C2H2-type 11.
 ZN_FING 515 537 C2H2-type 12.
 ZN_FING 543 565 C2H2-type 13.
 ZN_FING 571 593 C2H2-type 14.
 ZN_FING 599 621 C2H2-type 15.
 ZN_FING 627 649 C2H2-type 16.
 ZN_FING 655 677 C2H2-type 17.
 ZN_FING 683 705 C2H2-type 18.
 ZN_FING 711 733 C2H2-type 19.
 MOD_RES 128 128 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 738 AA 
Protein Sequence
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE VMKPDVIFKL 60
EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI IKRGHECDAF GKNFNLNMNF 120
VPLRKSNSEG DLDGLILKHH LDLLIPKGDY GKAESDDFNV FDNFFLHSKP EDTDTWLKYY 180
DCDKYKESYK KSQIIIYHRN RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC 240
GKTFPQKSQF ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 300
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR ECGKAFSRKS 360
QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE KPYECSECRK AFRERSSLIN 420
HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT 480
HTGEKPYECS ECGKAFSEKL SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE 540
KPYECSECGK AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 600
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT GEKPFECSEC 660
GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN HQRIHTGEKP YRCIECGKAF 720
SQKSQLINHQ RTHTVKKS 738 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS