UniProt Accession

 TOR3A_HUMAN; Q9H497; B4DSY0; B7ZB65; Q5M7Y7; Q8WVA7; Q8WWM2; Q9H495; Q9H6E7 

Genbank Protein ID

 AJ299403; AJ299441; AJ318044; AJ318045; AJ318046; AJ318047; AJ318048; AJ318049; AJ318044; AJ318045; AJ318046; AJ318047; AJ318048; AJ318050; AK025998; CR457354; AK299966; AK316530; AL139132; AL139132; BC001085; BC007571; BC011746; BC018292; BC088368 

Genbank Nucleotide ID

 CAC13973.1; CAC14461.1; CAC88129.1; CAC88129.1; CAC88129.1; CAC88129.1; CAC88129.1; CAC88129.1; CAC88130.1; CAC88130.1; CAC88130.1; CAC88130.1; CAC88130.1; CAC88130.1; BAB15312.1; CAG33635.1; BAG61792.1; BAH14901.1; CAH70928.1; CAH70929.1; AAH01085.1; AAH07571.1; AAH11746.1; AAH18292.1; AAH88368.1 

Protein Name

 Torsin-3A 

Protein Synonyms/Alias

 ATP-dependent interferon-responsive protein; Torsin family 3 member A 

Gene Name

 TOR3A 

Gene Synonyms/Alias

 ADIR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	TTWYCSFKDCCPRGD	ubiquitination	[1]
213	PKYVDLYKEQLMSQI	ubiquitination	[1, 2]
289	EVVLKLLKAGWSREE	ubiquitination	[1, 2]
325	FGHSRLVKENLIDYF	ubiquitination	[1]
386	LFSSQGCKSISQRIN	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

 NP_BIND 167 174 ATP (Potential).
 CARBOHYD 122 122 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Endoplasmic reticulum; Glycoprotein; Nucleotide-binding; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR010448; Torsin. 

Pfam

 PF06309; Torsin 

SMART

  

PROSITE

  

PRINTS