UniProt Accession

 DEFI8_HUMAN; Q6ZN54; B3KT65; B4DK62; B4E0S9; B7Z3H6; H3BUG7; Q8N8N3; Q9NXL0 

Genbank Protein ID

 AK000193; AK095051; AK096485; AK131370; AK295880; AK296410; AK303510; AC092143; CH471184; BC015482; BC105592 

Genbank Nucleotide ID

 BAA91000.1; BAG52977.1; BAC04802.1; BAD18521.1; BAH12212.1; BAG59074.1; BAG64541.1; EAW66667.1; AAH15482.1; AAI05593.1 

Protein Name

 Differentially expressed in FDCP 8 homolog 

Protein Synonyms/Alias

 DEF-8 

Gene Name

 DEF8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
67	DAMEYDEKLARFRQA	ubiquitination	[1]
81	AHLNPFNKQSGPRQH	ubiquitination	[1]
154	RQAIEECKQVILELP	ubiquitination	[2]
166	ELPEQSEKQKDAVVR	ubiquitination	[1]
180	RLIHLRLKLQELKDP	ubiquitination	[1, 2]
185	RLKLQELKDPNEDEP	ubiquitination	[1]
491	DNSTTCPKCARLSLR	ubiquitination	[2]
499	CARLSLRKQSLFQEP	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

 ZN_FING 199 250 Phorbol-ester/DAG-type 1.
 ZN_FING 429 489 Phorbol-ester/DAG-type 2.  

Keyword

 Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 512 AA 

Protein Sequence

Gene Ontology

 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 

Interpro

 IPR025258; DUF4206.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR001841; Znf_RING. 

Pfam

 PF00130; C1_1
 PF13901; DUF4206 

SMART

 SM00109; C1
 SM00184; RING 

PROSITE

 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 

PRINTS