| Tag | Content |
|---|
| CPLM ID | CPLM-001519 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Semaphorin-3D |
Protein Synonyms/Alias | |
Gene Name | SEMA3D |
Gene Synonyms/Alias | UNQ760/PRO1491 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 758 | KHMQEMKKKRNRRHH | methylation | [1] | | 759 | HMQEMKKKRNRRHHR | methylation | [1] |
|
Reference | [1] Large-scale global identification of protein lysine methylation in vivo. Cao XJ, Arnaudo AM, Garcia BA. Epigenetics. 2013 May 1;8(5):477-85. [ PMID: 23644510] |
Functional Description | Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). |
Sequence Annotation | DOMAIN 44 531 Sema.
DOMAIN 533 585 PSI.
DOMAIN 592 680 Ig-like C2-type.
CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).
CARBOHYD 607 607 N-linked (GlcNAc...) (Potential).
CARBOHYD 724 724 N-linked (GlcNAc...) (Potential).
DISULFID 117 128 By similarity.
DISULFID 146 155 By similarity.
DISULFID 286 398 By similarity.
DISULFID 310 358 By similarity.
DISULFID 534 552 By similarity.
DISULFID 665 731 By similarity. |
Keyword | Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Neurogenesis; Polymorphism; Reference proteome; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 777 AA |
Protein Sequence | MNANKDERLK ARSQDFHLFP ALMMLSMTML FLPVTGTLKQ NIPRLKLTYK DLLLSNSCIP 60
FLGSSEGLDF QTLLLDEERG RLLLGAKDHI FLLSLVDLNK NFKKIYWPAA KERVELCKLA 120
GKDANTECAN FIRVLQPYNK THIYVCGTGA FHPICGYIDL GVYKEDIIFK LDTHNLESGR 180
LKCPFDPQQP FASVMTDEYL YSGTASDFLG KDTAFTRSLG PTHDHHYIRT DISEHYWLNG 240
AKFIGTFFIP DTYNPDDDKI YFFFRESSQE GSTSDKTILS RVGRVCKNDV GGQRSLINKW 300
TTFLKARLIC SIPGSDGADT YFDELQDIYL LPTRDERNPV VYGVFTTTSS IFKGSAVCVY 360
SMADIRAVFN GPYAHKESAD HRWVQYDGRI PYPRPGTCPS KTYDPLIKST RDFPDDVISF 420
IKRHSVMYKS VYPVAGGPTF KRINVDYRLT QIVVDHVIAE DGQYDVMFLG TDIGTVLKVV 480
SISKEKWNME EVVLEELQIF KHSSIILNME LSLKQQQLYI GSRDGLVQLS LHRCDTYGKA 540
CADCCLARDP YCAWDGNACS RYAPTSKRRA RRQDVKYGDP ITQCWDIEDS ISHETADEKV 600
IFGIEFNSTF LECIPKSQQA TIKWYIQRSG DEHREELKPD ERIIKTEYGL LIRSLQKKDS 660
GMYYCKAQEH TFIHTIVKLT LNVIENEQME NTQRAEHEEG KVKDLLAESR LRYKDYIQIL 720
SSPNFSLDQY CEQMWHREKR RQRNKGGPKW KHMQEMKKKR NRRHHRDLDE LPRAVAT 777 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:InterPro. GO:0004872; F:receptor activity; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |