UniProt Accession

 IRF9_HUMAN; Q00978; D3DS61 

Genbank Protein ID

 M87503; CH471078; CH471078; BC035716 

Genbank Nucleotide ID

 AAA58687.1; EAW66093.1; EAW66094.1; AAH35716.1 

Protein Name

 Interferon regulatory factor 9 

Protein Synonyms/Alias

 IRF-9; IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; Transcriptional regulator ISGF3 subunit gamma 

Gene Name

 IRF9 

Gene Synonyms/Alias

 ISGF3G 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	TMFRIPWKHAGKQDF	acetylation	[1]
47	IPWKHAGKQDFREDQ	acetylation	[1]
68	AWAIFKGKYKEGDTG	acetylation	[1]
81	TGGPAVWKTRLRCAL	acetylation	[1]
90	RLRCALNKSSEFKEV	acetylation	[1]
110	MDVAEPYKVYQLLPP	acetylation	[1]
128	SGQPGTQKVPSKRQH	acetylation	[1]
132	GTQKVPSKRQHSSVS	acetylation	[1]

Reference

 [1] Acetylation-dependent signal transduction for type I interferon receptor.
 Tang X, Gao JS, Guan YJ, McLane KE, Yuan ZL, Ramratnam B, Chin YE.
 Cell. 2007 Oct 5;131(1):93-105. [PMID: 17923090] 

Functional Description

 Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. 

Sequence Annotation

 DNA_BIND 9 116 IRF tryptophan pentad repeat.  

Keyword

 Activator; Antiviral defense; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0045351; P:type I interferon biosynthetic process; IEA:Compara.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR019817; Interferon_reg_fac_CS.
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00605; IRF
 PF10401; IRF-3 

SMART

 SM00348; IRF 

PROSITE

 PS00601; IRF_1
 PS51507; IRF_2 

PRINTS

 PR00267; INTFRNREGFCT.