UniProt Accession

 ARP2_RAT; Q5M7U6 

Genbank Protein ID

 BC088442 

Genbank Nucleotide ID

 AAH88442.1 

Protein Name

 Actin-related protein 2 

Protein Synonyms/Alias

 Actin-like protein 2 

Gene Name

 Actr2 

Gene Synonyms/Alias

 Arp2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
118	EPPMNPTKNREKIVE	ubiquitination	[1]
299	DTRSEFYKHIVLSGG	acetylation	[2]
322	SRLERELKQLYLERV	acetylation	[2]
339	GDVEKLSKFKIRIED	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). 

Sequence Annotation

 NP_BIND 160 162 ATP (By similarity).
 NP_BIND 214 218 ATP (By similarity).
 NP_BIND 305 310 ATP (By similarity).
 MOD_RES 299 299 N6-acetyllysine (By similarity).
 MOD_RES 322 322 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; ATP-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR027306; Arp2. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.