CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034402
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-Va 
Protein Synonyms/Alias
  
Gene Name
 Myo5a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
174AGKTVSAKYAMRYFAubiquitination[1]
210MESIGNAKTTRNDNSubiquitination[1]
979QLSEEEAKVATGRVLubiquitination[1]
1207ELEYESLKRQELESEubiquitination[1]
1232LRKALSEKSAPEVTAubiquitination[1]
1277RSQLVSQKEAIQPKDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1855 AA 
Protein Sequence
MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY RLDPKTGELP 60
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 120
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 180
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 240
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADSFHYTKQ GGSPMIEGVD 300
DAKEMAHTRQ ACTLLGISES YQMGIFRILA GILHLGNVGF ASRDSDSCTI PPKHEPLTIF 360
CDLMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDHVN 420
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 480
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK 540
PRMSNKAFII KHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS 600
PTSATSSGRT PLTRVPVKPT KGRPGQTAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC 660
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL 720
GDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW 780
LLRKRYLCMQ RAAITVQRYV RGYQARCYAK FLRRTKAATT IQKYWRMYVV RRRYKIRRAA 840
TIVIQSYLRG YLTRNRYRKI LREYKAVIIQ KRVRGWLART HYKRTMKAIV YLQCCFRRMM 900
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLMEKL TNLEGVYNSE 960
TEKLRNDVER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKSIE ERADKYKQET 1020
DQLVSNLKEE NTLLKQEKET LNHRIVEQAK EMTETMERKL VEETKQLELD LNDERLRYQN 1080
LLNEFSRLEE RYDDLKEEMT LMLNVPKPGH KRTDSTHSSN ESEYTFSSEF AETEDIAPRT 1140
EEPIEKKVPL DMSLFLKLQK RVTELEQEKQ LMQDELDRKE EQVFRSKAKE EERPQIRGAE 1200
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD 1260
VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR 1320
SSTMDYQELN EDGELWMVYE GLKQANRLLE SQLQSQKRSH ENEAEALRGE IQSLKEENNR 1380
QQQLLAQNLQ LPPEARIEAS LQHEITRLTN ENLDLMEQLE KQDKTVRKLK KQLKVFAKKI 1440
GELEVGQMEN ISPGQIIDEP IRPVNIPRKE KDFQGMLEYK REDEQKLVKN LILELKPRGV 1500
AVNLIPGLPA YILFMCVRHA DYLNDDQKVR SLLTSTINSI KKVLKKRGDD FETVSFWLSN 1560
TCRFLHCLKQ YSGEEGFMKH NTSRQNEHCL TNFDLAEYRQ VLSDLAIQIY QQLVRVLENI 1620
LQPMIVSGML EHETIQGVSG VKPTGLRKRT SSIADEGTYT LDSILRQLNS FHSVMCQHGM 1680
DPELIKQVVK QMFYIVGAIT LNNLLLRKDM CSWSKGMQIR YNVSQLEEWL RDKNLMNSGA 1740
KETLEPLIQA AQLLQVKKKT DDDAEAICSM CNALTTAQIV KVLNLYTPVN EFEERVSVSF 1800
IRTIQMRLRD RKDSPQLLMD AKHIFPVTFP FNPSSLALET IQIPASLGLG FIARV 1855 
Gene Ontology
 GO:0042641; C:actomyosin; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005882; C:intermediate filament; IDA:MGI.
 GO:0042470; C:melanosome; IDA:MGI.
 GO:0035371; C:microtubule plus end; IDA:MGI.
 GO:0016459; C:myosin complex; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0001750; C:photoreceptor outer segment; IDA:MGI.
 GO:0030141; C:secretory granule; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0005516; F:calmodulin binding; IDA:MGI.
 GO:0000146; F:microfilament motor activity; IDA:MGI.
 GO:0042640; P:anagen; IMP:MGI.
 GO:0051643; P:endoplasmic reticulum localization; IMP:MGI.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0030073; P:insulin secretion; IMP:MGI.
 GO:0031987; P:locomotion involved in locomotory behavior; IMP:MGI.
 GO:0042759; P:long-chain fatty acid biosynthetic process; IMP:MGI.
 GO:0042438; P:melanin biosynthetic process; IMP:MGI.
 GO:0030318; P:melanocyte differentiation; IMP:MGI.
 GO:0032402; P:melanosome transport; IDA:MGI.
 GO:0042552; P:myelination; IMP:MGI.
 GO:0042476; P:odontogenesis; IDA:MGI.
 GO:0031585; P:regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IMP:MGI.
 GO:0032252; P:secretory granule localization; IMP:MGI.
 GO:0050808; P:synapse organization; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI.
 GO:0030050; P:vesicle transport along actin filament; TAS:MGI.
 GO:0007601; P:visual perception; IMP:MGI. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01843; DIL
 PF00612; IQ
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS51126; DILUTE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.