CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027539
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 EH-domain containing 1 
Protein Synonyms/Alias
  
Gene Name
 Ehd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35SKDARRKKEPELFQTubiquitination[1]
54LRQLYAQKLLPLEEHubiquitination[1]
80EDADFDNKPMVLLVGubiquitination[1]
146DPRRPFRKLNAFGNAubiquitination[1]
184PGILSGEKQRISRGYubiquitination[1]
227DEFSEVIKALKNHEDubiquitination[1]
242KIRVVLNKADQIETQubiquitination[1]
291LLIPDNRKLFEAEEQubiquitination[1]
315PRNAALRKLNDLIKRubiquitination[1]
321RKLNDLIKRARLAKVubiquitination[1]
363NLGEIYQKIEREHQIubiquitination[1]
380GDFPSLRKMQELLQTubiquitination[1]
392LQTQDFSKFQALKPKubiquitination[1]
531ALANHLIKVKLEGHEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 556 AA 
Protein Sequence
PRVRPRVRPP LRPVAASPVS GIMFSWVSKD ARRKKEPELF QTVAEGLRQL YAQKLLPLEE 60
HYRFHEFHSP ALEDADFDNK PMVLLVGQYS TGKTTFIRHL IEQDFPGMRI GPEPTTDSFI 120
AVMHGPTEGV VPGNALVVDP RRPFRKLNAF GNAFLNRFMC AQLPNPVLDS ISIIDTPGIL 180
SGEKQRISRG YDFAAVLEWF AERVDRIILL FDAHKLDISD EFSEVIKALK NHEDKIRVVL 240
NKADQIETQQ LMRVYGALMW SLGKIINTPE VVRVYIGSFW SHPLLIPDNR KLFEAEEQDL 300
FKDIQSLPRN AALRKLNDLI KRARLAKVHA YIISSLKKEM PNVFGKESKK KELVNNLGEI 360
YQKIEREHQI SSGDFPSLRK MQELLQTQDF SKFQALKPKL LDTVDDMLAN DIARLMVMVR 420
QEESLMPSQA VKGGAFDGTM NGPFGHGYGE GAGEGIDDVE WVVGKDKPTY DEIFYTLSPV 480
NGKITGANAK KEMVKSKLPN TVLGKIWKLA DVDKDGLLDD EEFALANHLI KVKLEGHELP 540
ADLPPHLIPP SKRRHE 556 
Gene Ontology
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0031901; C:early endosome membrane; IEA:Compara.
 GO:0030139; C:endocytic vesicle; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0055038; C:recycling endosome membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0032456; P:endocytic recycling; IEA:Compara.
 GO:0006897; P:endocytosis; IDA:MGI.
 GO:0016197; P:endosomal transport; IDA:MGI.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N 
SMART
 SM00027; EH 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH 
PRINTS