CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010261
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucose 6-dehydrogenase 
Protein Synonyms/Alias
 UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH 
Gene Name
 ugd 
Gene Synonyms/Alias
 pmrE; udg; yefA; b2028; JW2010 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
48RISPIVDKEIQQFLQacetylation[1]
58QQFLQSDKIHFNATLacetylation[1]
67HFNATLDKNEAYRDAacetylation[1]
88TPTDYDPKTNYFNTSacetylation[1]
129GFTAAMHKKYRTENIacetylation[1]
147PEFLREGKALYDNLHacetylation[1]
256YGGYCLPKDTKQLLAacetylation[1]
284VDANRTRKDFIADAIacetylation[1]
323SSIQGIMKRIKAKGVacetylation[1]
373NRMAEELKDVADKVYacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 NP_BIND 2 19 NAD (Potential).
 ACT_SITE 253 253 By similarity.  
Keyword
 Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI QQFLQSDKIH 60
FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV IKDVVEINPY AVMVIKSTVP 120
VGFTAAMHKK YRTENIIFSP EFLREGKALY DNLHPSRIVI GERSERAERF AALLQEGAIK 180
QNIPMLFTDS TEAEAIKLFA NTYLAMRVAY FNELDSYAES LGLNSRQIIE GVCLDPRIGN 240
HYNNPSFGYG GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RTRKDFIADA ILSRKPQVVG 300
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVMK EDSFFNSRLE RDLATFKQQA 360
DVIISNRMAE ELKDVADKVY TRDLFGSD 388 
Gene Ontology
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IMP:EcoliWiki.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006065; P:UDP-glucuronate biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom.
 IPR017476; Nucleotide_sugar_DH.
 IPR014027; UDP-Glc/GDP-Man_DH_C.
 IPR014026; UDP-Glc/GDP-Man_DH_dimer.
 IPR001732; UDP-Glc/GDP-Man_DH_N. 
Pfam
 PF00984; UDPG_MGDP_dh
 PF03720; UDPG_MGDP_dh_C
 PF03721; UDPG_MGDP_dh_N 
SMART
 SM00984; UDPG_MGDP_dh_C 
PROSITE
  
PRINTS