| Tag | Content |
|---|
| CPLM ID | CPLM-001655 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 8 |
Protein Synonyms/Alias | AD 3; Vascular Rab-GAP/TBC-containing protein |
Gene Name | TBC1D8 |
Gene Synonyms/Alias | VRP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | QEPSQITKRDLEARA | ubiquitination | [1] | | 527 | LIRDSYEKFGDQSVE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). |
Sequence Annotation | DOMAIN 145 212 GRAM 1.
DOMAIN 285 353 GRAM 2.
DOMAIN 505 692 Rab-GAP TBC. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1140 AA |
Protein Sequence | MEQLADVTLR RLLDNEVFDL DPDLQEPSQI TKRDLEARAQ NEFFRAFFRL PRKEKLHAVV 60
DCSLWTPFSR CHTTGRMFAS DSYICFASRE DGCCKIILPL REVVSIEKME DTSLLPHPII 120
VSIRSKVAFQ FIELRDRDSL VEALLARLKQ VHANHPVHYD TSADDDMASL VFHSTSMCSD 180
HRFGDLEMMS SQNSEESEKE KSPLMHPDAL VTAFQQSGSQ SPDSRMSREQ IKISLWNDHF 240
VEYGRTVCMF RTEKIRKLVA MGIPESLRGR LWLLFSDAVT DLASHPGYYG NLVEESLGKC 300
CLVTEEIERD LHRSLPEHPA FQNETGIAAL RRVLTAYAHR NPKIGYCQSM NILTSVLLLY 360
TKEEEAFWLL VAVCERMLPD YFNHRVIGAQ VDQSVFEELI KGHLPELAEH MNDLSALASV 420
SLSWFLTLFL SIMPLESAVN VVDCFFYDGI KAIFQLGLAV LEANAEDLCS SKDDGQALMI 480
LSRFLDHIKN EDSPGPPVGS HHAFFSDDQE PYPVTDISDL IRDSYEKFGD QSVEQIEHLR 540
YKHRIRVLQG HEDTTKQNVL RVVIPEVSIL PEDLEELYDL FKREHMMSCY WEQPRPMASR 600
HDPSRPYAEQ YRIDARQFAH LFQLVSPWTC GAHTEILAER TFRLLDDNMD QLIEFKAFVS 660
CLDIMYNGEM NEKIKLLYRL HIPPALTEND RDSQSPLRNP LLSTSRPLVF GKPNGDAVDY 720
QKQLKQMIKD LAKEKDKTEK ELPKMSQREF IQFCKTLYSM FHEDPEENDL YQAIATVTTL 780
LLQIGEVGQR GSSSGSCSQE CGEELRASAP SPEDSVFADT GKTPQDSQAF PEAAERDWTV 840
SLEHILASLL TEQSLVNFFE KPLDMKSKLE NAKINQYNLK TFEMSHQSQS ELKLSNL 897 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0016020; C:membrane; TAS:ProtInc. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0008015; P:blood circulation; TAS:ProtInc. GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |