UniProt Accession

 SPRE1_HUMAN; Q7Z699; B2RPJ8; Q05D53; Q8N256 

Genbank Protein ID

 AY299089; AK091222; CH471125; BC018015; BC137480; BC137481 

Genbank Nucleotide ID

 AAP59414.1; BAC03614.1; EAW92368.1; AAH18015.1; AAI37481.1; AAI37482.1 

Protein Name

 Sprouty-related, EVH1 domain-containing protein 1 

Protein Synonyms/Alias

 Spred-1; hSpred1 

Gene Name

 SPRED1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
312	PKDSVVFKTQPSSLK	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). 

Sequence Annotation

 DOMAIN 6 123 WH1.
 DOMAIN 233 285 KBD.
 DOMAIN 334 442 SPR.
 MOD_RES 238 238 Phosphoserine (By similarity).  

Keyword

 3D-structure; Cell membrane; Complete proteome; Disease mutation; Membrane; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 444 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISS:BHF-UCL.
 GO:0005173; F:stem cell factor receptor binding; ISS:UniProtKB.
 GO:0000188; P:inactivation of MAPK activity; ISS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:BHF-UCL.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; ISS:BHF-UCL.
 GO:0090311; P:regulation of protein deacetylation; ISS:BHF-UCL. 

Interpro

 IPR000697; EVH1.
 IPR023337; KBD.
 IPR011993; PH_like_dom.
 IPR007875; Sprouty. 

Pfam

 PF05210; Sprouty
 PF00568; WH1 

SMART

  

PROSITE

 PS51488; KBD
 PS51227; SPR
 PS50229; WH1 

PRINTS