CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023529
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP:AMP phosphotransferase AK4, mitochondrial 
Protein Synonyms/Alias
 Adenylate kinase 3-like; Adenylate kinase isoenzyme 4; AK 4 
Gene Name
 Ak4 
Gene Synonyms/Alias
 Ak3l1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
4****MASKLLRAVILacetylation[1]
55TEVGDVAKQYLEKGLacetylation[1]
60VAKQYLEKGLLVPDHacetylation[1]
163LVQQEDDKPEALAARacetylation[1]
175AARLRRYKDAAKPVIacetylation[1]
179RRYKDAAKPVIELYKacetylation[1]
186KPVIELYKSRGVLHQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). 
Sequence Annotation
 NP_BIND 15 20 NTP (By similarity).
 NP_BIND 62 64 AMP (By similarity).
 NP_BIND 89 92 AMP (By similarity).
 NP_BIND 135 136 NTP (By similarity).
 REGION 35 64 NMPbind (By similarity).
 REGION 125 162 LID (By similarity).
 BINDING 36 36 AMP (By similarity).
 BINDING 41 41 AMP (By similarity).
 BINDING 96 96 AMP (By similarity).
 BINDING 126 126 NTP (By similarity).
 BINDING 170 170 AMP (By similarity).
 BINDING 199 199 NTP; via carbonyl oxygen (By similarity).  
Keyword
 ATP-binding; Complete proteome; GTP-binding; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MASKLLRAVI LGPPGSGKGT VCERIAQNFG LQHLSSGHLL RENLKTNTEV GDVAKQYLEK 60
GLLVPDHVIT RLMMSELETR SAQHWLLDGF PRTLVQAEAL DRICDVDLVI SLNIPFETLK 120
DRLSRRWIHP SSGRVYNLDF NPPQVLGVDD ITGEPLVQQE DDKPEALAAR LRRYKDAAKP 180
VIELYKSRGV LHQFSGTETN RIWPYVYTLF SNKITPIQSK EAY 223 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0004017; F:adenylate kinase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046899; F:nucleoside triphosphate adenylate kinase activity; IEA:EC.
 GO:0046033; P:AMP metabolic process; IEA:Compara.
 GO:0046034; P:ATP metabolic process; IEA:Compara.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0018885; P:carbon tetrachloride metabolic process; IEP:RGD.
 GO:0046039; P:GTP metabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0043643; P:tetracycline metabolic process; IEP:RGD. 
Interpro
 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00406; ADK
 PF05191; ADK_lid 
SMART
  
PROSITE
 PS00113; ADENYLATE_KINASE 
PRINTS
 PR00094; ADENYLTKNASE.