UniProt Accession

 ANF_RAT; P01161 

Genbank Protein ID

 M15868; X00665; K02062; X01118; M27498 

Genbank Nucleotide ID

 AAA40736.1; CAA25285.1; AAA40735.1; CAA25586.1; AAA40737.1 

Protein Name

 Natriuretic peptides A 

Protein Synonyms/Alias

 Prepronatriodilatin; Atrial natriuretic factor; ANF; Atrial natriuretic peptide; ANP; Auriculin-B; Auriculin-A; Atriopeptin-1; Atriopeptin I; Atriopeptin-2; Atriopeptin II; Atriopeptin-3; Atriopeptin III 

Gene Name

 Nppa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
111	SDRSALLKSKLRALL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). 

Sequence Annotation

 DISULFID 129 145  

Keyword

 3D-structure; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Hormone; Reference proteome; Secreted; Signal; Vasoactive. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0042629; C:mast cell granule; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005179; F:hormone activity; IDA:RGD.
 GO:0051428; F:peptide hormone receptor binding; IDA:RGD.
 GO:0014898; P:cardiac muscle hypertrophy in response to stress; IEA:Compara.
 GO:0006182; P:cGMP biosynthetic process; IDA:RGD.
 GO:0007565; P:female pregnancy; ISS:UniProtKB.
 GO:0007507; P:heart development; TAS:UniProtKB.
 GO:0050891; P:multicellular organismal water homeostasis; TAS:RGD.
 GO:0030308; P:negative regulation of cell growth; IMP:RGD.
 GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
 GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
 GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
 GO:0042312; P:regulation of vasodilation; TAS:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD. 

Interpro

 IPR000663; Natr_peptide.
 IPR002407; Natriuretic_peptide_atrial. 

Pfam

 PF00212; ANP 

SMART

 SM00183; NAT_PEP 

PROSITE

 PS00263; NATRIURETIC_PEPTIDE 

PRINTS

 PR00711; ANATPEPTIDE.
 PR00710; NATPEPTIDES.