UniProt Accession

 DEOC_ECOLI; P0A6L0; P00882; Q2M5T6 

Genbank Protein ID

 X03224; U14003; U00096; AP009048 

Genbank Nucleotide ID

 CAA26974.1; AAA97277.1; AAC77334.1; BAE78370.1 

Protein Name

 Deoxyribose-phosphate aldolase 

Protein Synonyms/Alias

 DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase 

Gene Name

 deoC 

Gene Synonyms/Alias

 dra; thyR; b4381; JW4344 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
13	ASSLRALKLMDLTTL	acetylation	[1]
28	NDDDTDEKVIALCHQ	acetylation	[1]
61	PIARKTLKEQGTPEI	acetylation	[1]
146	IIETGELKDEALIRK	acetylation	[1]
160	KASEISIKAGADFIK	acetylation	[1]
167	KAGADFIKTSTGKVA	acetylation	[1, 2]
196	IRDMGVEKTVGFKPA	acetylation	[1, 3]
214	RTAEDAQKYLAIADE	acetylation	[1]
246	SLLASLLKALGHGDG	acetylation	[1]
254	ALGHGDGKSASSY**	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. 

Sequence Annotation

 ACT_SITE 167 167 Schiff-base intermediate with
 ACT_SITE 201 201
 MOD_RES 167 167 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Lyase; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0004139; F:deoxyribose-phosphate aldolase activity; IDA:EcoliWiki.
 GO:0016052; P:carbohydrate catabolic process; IDA:EcoliWiki.
 GO:0009264; P:deoxyribonucleotide catabolic process; IMP:EcoliWiki.
 GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IMP:EcoliWiki.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR011343; DeoC.
 IPR002915; DeoC/FbaB/lacD_aldolase.
 IPR023649; DeoC_bac. 

Pfam

 PF01791; DeoC 

SMART

  

PROSITE

  

PRINTS