CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vitronectin 
Protein Synonyms/Alias
 VN; S-protein; Serum-spreading factor 
Gene Name
 Vtn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
222QGKTYLFKGSQYWRFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. 
Sequence Annotation
 DOMAIN 20 63 SMB.
 REPEAT 157 201 Hemopexin 1.
 REPEAT 202 249 Hemopexin 2.
 REPEAT 250 304 Hemopexin 3.
 REPEAT 420 473 Hemopexin 4.
 REGION 366 399 Heparin-binding (By similarity).
 MOTIF 64 66 Cell attachment site.
 MOD_RES 69 69 Phosphothreonine (By similarity).
 MOD_RES 75 75 Sulfotyrosine (Potential).
 MOD_RES 78 78 Sulfotyrosine (Potential).
 MOD_RES 80 80 Sulfotyrosine (Potential).
 MOD_RES 278 278 Sulfotyrosine (Potential).
 MOD_RES 281 281 Sulfotyrosine (Potential).
 MOD_RES 311 311 Phosphoserine (By similarity).
 MOD_RES 398 398 Phosphoserine; by PKA (By similarity).
 MOD_RES 416 416 Sulfotyrosine (Potential).
 MOD_RES 419 419 Sulfotyrosine (Potential).
 MOD_RES 421 421 Sulfotyrosine (Potential).
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 241 241 N-linked (GlcNAc...).
 DISULFID 24 40 Alternate; alternate (By similarity).
 DISULFID 24 28 Alternate; alternate (By similarity).
 DISULFID 28 58 Alternate; alternate (By similarity).
 DISULFID 38 51 Alternate; alternate (By similarity).
 DISULFID 38 40 Alternate; alternate (By similarity).
 DISULFID 44 50 By similarity.
 DISULFID 51 58 Alternate; alternate (By similarity).
 DISULFID 292 431 By similarity.  
Keyword
 Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Sulfation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MAPLRPFFIL ALVAWVSLAD QESCKGRCTQ GFMASKKCQC DELCTYYQSC CADYMEQCKP 60
QVTRGDVFTM PEDDYWSYDY VEEPKNNTNT GVQPENTSPP GDLNPRTDGT LKPTAFLDPE 120
EQPSTPAPKV EQQEEILRPD TTDQGTPEFP EEELCSGKPF DAFTDLKNGS LFAFRGQYCY 180
ELDETAVRPG YPKLIQDVWG IEGPIDAAFT RINCQGKTYL FKGSQYWRFE DGVLDPGYPR 240
NISEGFSGIP DNVDAAFALP AHRYSGRERV YFFKGKQYWE YEFQQQPSQE ECEGSSLSAV 300
FEHFALLQRD SWENIFELLF WGRSSDGARE PQFISRNWHG VPGKVDAAMA GRIYVTGSLS 360
HSAQAKKQKS KRRSRKRYRS RRGRGHRRSQ SSNSRRSSRS IWFSLFSSEE SGLGTYNNYD 420
YDMDWLVPAT CEPIQSVYFF SGDKYYRVNL RTRRVDSVNP PYPRSIAQYW LGCPTSEK 478 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:MGI.
 GO:0050840; F:extracellular matrix binding; IDA:MGI.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0030247; F:polysaccharide binding; IEA:InterPro.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0033627; P:cell adhesion mediated by integrin; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IDA:MGI.
 GO:0030198; P:extracellular matrix organization; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0010951; P:negative regulation of endopeptidase activity; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:MGI.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Compara.
 GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Compara.
 GO:0061302; P:smooth muscle cell-matrix adhesion; IEA:Compara. 
Interpro
 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR020436; Somatomedin_B_chordata.
 IPR001212; Somatomedin_B_dom. 
Pfam
 PF00045; Hemopexin
 PF01033; Somatomedin_B 
SMART
 SM00120; HX
 SM00201; SO 
PROSITE
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00524; SMB_1
 PS50958; SMB_2 
PRINTS
 PR00022; SOMATOMEDINB.