CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ52712, highly similar to Tubulin beta-6 chain 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58YNESSSQKYVPRAALubiquitination[1, 2]
296FRGPMSMKEVDEQMLubiquitination[2]
308QMLAIQSKNSSYFVEubiquitination[2]
322EWIPNNVKVAVCDIPubiquitination[2]
334DIPPRGLKMASTFIGubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). 
Sequence Annotation
  
Keyword
 Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MREIVHIQAG QCGNQIGTKF WEVISDEHGI DPAGGYVGDS ALQLERINVY YNESSSQKYV 60
PRAALVDLEP GTMDSVRSGP FGQLFRPDNF IFGQTGAGNN CLQGFQLTHS LGGGTGSGMG 120
TLLISKIREE FPDRIMNTFS VMPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY 180
DICFRTLKLT TPTYGDLNHL VSATMSGVTT SLRFPGQLNA DLRKLAVNMV PFPRLHFFMP 240
GFAPLTSRGS QQYRALTVPE LTQQMFDARN MMAACDPRHG RYLTVATVFR GPMSMKEVDE 300
QMLAIQSKNS SYFVEWIPNN VKVAVCDIPP RGLKMASTFI GNSTAIQELF KRISEQFSAM 360
FRRKAFLHWF TGEGMDEMEF TEAESNMNDL VSEYQQYQDA TANDGEEAFE DEEEEIDG 418 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0007017; P:microtubule-based process; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro. 
Interpro
 IPR013838; Beta-tubulin_BS.
 IPR002453; Beta_tubulin.
 IPR019605; Misato_II_myosin-like.
 IPR008280; Tub_FtsZ_C.
 IPR000217; Tubulin.
 IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
 IPR023123; Tubulin_C.
 IPR017975; Tubulin_CS.
 IPR003008; Tubulin_FtsZ_GTPase. 
Pfam
 PF10644; Misat_Myo_SegII
 PF00091; Tubulin
 PF03953; Tubulin_C 
SMART
 SM00864; Tubulin
 SM00865; Tubulin_C 
PROSITE
 PS00227; TUBULIN
 PS00228; TUBULIN_B_AUTOREG 
PRINTS
 PR01163; BETATUBULIN.
 PR01161; TUBULIN.