UniProt Accession

 ADH3_YEAST; P07246; D6VZQ6 

Genbank Protein ID

 K03292; Z49259; AY692988; BK006946 

Genbank Nucleotide ID

 AAA34409.1; CAA89229.1; AAT93007.1; DAA09980.1 

Protein Name

 Alcohol dehydrogenase 3, mitochondrial 

Protein Synonyms/Alias

 Alcohol dehydrogenase III; YADH-3 

Gene Name

 ADH3 

Gene Synonyms/Alias

 YMR083W; YM9582.08 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
43	GVIFYENKGKLHYKD	acetylation	[1]
49	NKGKLHYKDIPVPEP	acetylation	[1]
111	GSNVKGWKVGDLAGI	acetylation	[1]
234	GIDAGEEKEKLFKKL	acetylation	[1]
342	FFSRGLIKSPIKIVG	ubiquitination	[2]
346	GLIKSPIKIVGLSEL	acetylation	[1]
355	VGLSELPKVYDLMEK	acetylation	[1]
362	KVYDLMEKGKILGRY	acetylation	[1]
362	KVYDLMEKGKILGRY	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 NP_BIND 205 211 NAD (By similarity).
 NP_BIND 296 298 NAD (By similarity).
 METAL 71 71 Zinc 1; catalytic.
 METAL 94 94 Zinc 1; catalytic.
 METAL 125 125 Zinc 2.
 METAL 128 128 Zinc 2.
 METAL 131 131 Zinc 2.
 METAL 139 139 Zinc 2.
 METAL 181 181 Zinc 1; catalytic.
 BINDING 229 229 NAD (By similarity).
 BINDING 234 234 NAD (By similarity).
 BINDING 368 368 NAD (By similarity).  

Keyword

 Complete proteome; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000947; P:amino acid catabolic process to alcohol via Ehrlich pathway; IGI:SGD.
 GO:0006113; P:fermentation; ISS:SGD.
 GO:0006116; P:NADH oxidation; IDA:SGD. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS