CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014606
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 7B 
Protein Synonyms/Alias
 Krueppel-related zinc finger protein cKrox; c-Krox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger protein 67; Zfp-67; Zinc finger protein Th-POK 
Gene Name
 Zbtb7b 
Gene Synonyms/Alias
 Thpok; Zfp67 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
210RRSRKPRKAFLQTKGacetylation[1]
216RKAFLQTKGARANHLacetylation[1]
339PGLDGQDKLVRKRRSacetylation[1]
Reference
 [1] p300-mediated acetylation stabilizes the Th-inducing POK factor.
 Zhang M, Zhang J, Rui J, Liu X.
 J Immunol. 2010 Oct 1;185(7):3960-9. [PMID: 20810990] 
Functional Description
 Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. 
Sequence Annotation
 DOMAIN 34 115 BTB.
 ZN_FING 350 372 C2H2-type 1.
 ZN_FING 378 400 C2H2-type 2.
 ZN_FING 406 428 C2H2-type 3.
 ZN_FING 434 458 C2H2-type 4; atypical.
 MOD_RES 373 373 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Developmental protein; Differentiation; Disease mutation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 60
KLFTEGGGGT VMGTGGGGTA SGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 120
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT TTASTSGMPN 180
GEDSPPQVPL LPPPPPPPRP VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLTYEEE 240
EMVGRLGNSG GSGLGDSYSP PTGAASPAEG PLNYEVFEGE EEEEEMAYPP GYGLAQSNEP 300
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL TPGLDGQDKL VRKRRSQMPQ ECPVCHKIIH 360
GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH TGERPYSCPH CPARFLHSYD 420
LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ RHLKGQNCLE VRTRRRRKDD VAAPHYPPPS 480
TTTSSPAGLD LSNGHLDTFH LSLARFWEQS ATTGPPVTTQ GPPEEEEEEG TPTTPQAEGA 540
MESS 544 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0043370; P:regulation of CD4-positive, alpha-beta T cell differentiation; IMP:MGI.
 GO:0043376; P:regulation of CD8-positive, alpha-beta T cell differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS