UniProt Accession

 WASF2_HUMAN; Q9Y6W5; B4DZN0; O60794; Q9UDY7 

Genbank Protein ID

 AB026542; AK303011; AL096774; AL663122; BX293535; BC040943 

Genbank Nucleotide ID

 BAA81795.1; BAG64142.1; CAC18518.1; AAH40943.1 

Protein Name

 Wiskott-Aldrich syndrome protein family member 2 

Protein Synonyms/Alias

 WASP family protein member 2; Protein WAVE-2; Verprolin homology domain-containing protein 2 

Gene Name

 WASF2 

Gene Synonyms/Alias

 WAVE2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
161	SYFFDLWKEKMLQDT	ubiquitination	[1]
169	EKMLQDTKDIMKEKR	acetylation	[2]
216	GQEFVESKEKLGTSG	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. 

Sequence Annotation

 DOMAIN 436 453 WH2.  

Keyword

 3D-structure; Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 498 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0003779; F:actin binding; TAS:ProtInc.
 GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
 GO:0030048; P:actin filament-based movement; IEA:Compara.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0001667; P:ameboidal cell migration; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0016601; P:Rac protein signal transduction; IEA:Compara. 

Interpro

 IPR003124; WH2_dom. 

Pfam

 PF02205; WH2 

SMART

 SM00246; WH2 

PROSITE

 PS51082; WH2 

PRINTS