UniProt Accession

 LFA3_HUMAN; P19256; A8K7G5; Q5U053; Q6IB65; Q96KI9 

Genbank Protein ID

 Y00636; X06296; Y14780; Y14781; Y14782; Y14783; Y14784; Y14780; Y14781; Y14782; Y14783; Y14784; Y14785; AK291980; CR456939; BT019816; BT019817; AL390066; AL355794; AL355794; AL390066; CH471122; CH471122 

Genbank Nucleotide ID

 CAA68668.1; CAA29622.1; CAA75083.1; CAA75083.1; CAA75083.1; CAA75083.1; CAA75083.1; CAA75084.1; CAA75084.1; CAA75084.1; CAA75084.1; CAA75084.1; CAA75084.1; BAF84669.1; CAG33220.1; AAV38619.1; AAV38620.1; CAI19099.1; CAI19099.1; CAI22762.1; CAI22762.1; EAW56652.1; EAW56653.1 

Protein Name

 Lymphocyte function-associated antigen 3 

Protein Synonyms/Alias

 Ag3; Surface glycoprotein LFA-3; CD58 

Gene Name

 CD58 

Gene Synonyms/Alias

 LFA3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	FRAFSSFKNRVYLDT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. 

Sequence Annotation

 DOMAIN 135 194 Ig-like C2-type.
 CARBOHYD 40 40 N-linked (GlcNAc...).
 CARBOHYD 94 94 N-linked (GlcNAc...).
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
 CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
 DISULFID 142 187 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0016337; P:cell-cell adhesion; NAS:UniProtKB.
 GO:0050900; P:leukocyte migration; TAS:Reactome. 

Interpro

 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR015714; Lymphocyte_func-assoc_Ag_3. 

Pfam

  

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS