CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038043
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dynamin-1-like protein 
Protein Synonyms/Alias
  
Gene Name
 Dnm1l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
173VPVGDQPKDIELQIRubiquitination[1]
251MGRVIPVKLGIIGVVubiquitination[1]
318RDCLPELKTRINVLAubiquitination[1]
573RGMLKTSKAEELLAEacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 712 AA 
Protein Sequence
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 60
RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 120
RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 180
ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 240
DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 300
TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 360
IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 420
VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 480
VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 540
GSRDKVPSAG GGIGDGGQEP TTGNWRGMLK TSKAEELLAE EKSKPIPIMP ASPQKGHAVN 600
LLDVPVPVAR KLSAREQRDC EVIERLIKSY FLIVRKNIQD SVPKAVMHFL VNHVKDTLQS 660
ELVGQLYKSS LLDDLLTESE DMAQRRKEAA DMLKALQGAS QIIAEIRETH LW 712 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005777; C:peroxisome; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003374; P:dynamin polymerization involved in mitochondrial fission; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0090149; P:membrane fission involved in mitochondrial fission; IEA:Compara.
 GO:0000266; P:mitochondrial fission; IMP:MGI.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IEA:Compara.
 GO:0070584; P:mitochondrion morphogenesis; IEA:Compara.
 GO:0016559; P:peroxisome fission; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0050714; P:positive regulation of protein secretion; IEA:Compara.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:1900063; P:regulation of peroxisome organization; IEA:Compara. 
Interpro
 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED 
SMART
 SM00053; DYNc
 SM00302; GED 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED 
PRINTS
 PR00195; DYNAMIN.