CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021631
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial thiamine pyrophosphate carrier 
Protein Synonyms/Alias
 Mitochondrial uncoupling protein 1; Solute carrier family 25 member 19 
Gene Name
 SLC25A19 
Gene Synonyms/Alias
 DNC; MUP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
153FAAQGEPKVYNTLRHubiquitination[1]
275CAKQVLQKEGALGFFubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. 
Sequence Annotation
 REPEAT 13 106 Solcar 1.
 REPEAT 116 202 Solcar 2.
 REPEAT 214 309 Solcar 3.
 MOTIF 241 246 Substrate recognition (By similarity).  
Keyword
 Complete proteome; Disease mutation; Membrane; Mitochondrion; Mitochondrion inner membrane; Neuropathy; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MVGYDPKPDG RNNTKFQVAV AGSVSGLVTR ALISPFDVIK IRFQLQHERL SRSDPSAKYH 60
GILQASRQIL QEEGPTAFWK GHVPAQILSI GYGAVQFLSF EMLTELVHRG SVYDAREFSV 120
HFVCGGLAAC MATLTVHPVD VLRTRFAAQG EPKVYNTLRH AVGTMYRSEG PQVFYKGLAP 180
TLIAIFPYAG LQFSCYSSLK HLYKWAIPAE GKKNENLQNL LCGSGAGVIS KTLTYPLDLF 240
KKRLQVGGFE HARAAFGQVR RYKGLMDCAK QVLQKEGALG FFKGLSPSLL KAALSTGFMF 300
FSYEFFCNVF HCMNRTASQR 320 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; NAS:UniProtKB.
 GO:0030233; F:deoxynucleotide transmembrane transporter activity; TAS:UniProtKB. 
Interpro
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00926; MITOCARRIER.