CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 138 
Protein Synonyms/Alias
  
Gene Name
 CCDC138 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19DLVVESLKSRYGLGGubiquitination[1, 2, 3, 4]
41FSNFYQSKYKRRTLTubiquitination[2, 3]
60LDIYSGDKVGSSLKYubiquitination[3]
66DKVGSSLKYSDESKHubiquitination[3, 5]
83TPLGSLFKHVNVNCLubiquitination[6]
102DSFHDLKKQETEEELubiquitination[3, 5]
123VSTSKITKQSFKEIEubiquitination[3]
127KITKQSFKEIEKVALubiquitination[3]
131QSFKEIEKVALPTNTubiquitination[3]
157DAGDSPLKPVSCPKSubiquitination[2, 3]
163LKPVSCPKSKASDKRubiquitination[3]
165PVSCPKSKASDKRSLubiquitination[3]
200CETAAQQKFAEELQKubiquitination[3]
207KFAEELQKRERFLLEubiquitination[3]
228RHENALSKIKGVEEEubiquitination[3]
230ENALSKIKGVEEEVLubiquitination[3, 5]
244LTRFQIIKEQHDAEVubiquitination[3]
259EHLTEVLKEKNKETKubiquitination[3]
276RSSFDALKELNDTLKubiquitination[3]
283KELNDTLKKQLNEASubiquitination[3]
284ELNDTLKKQLNEASEubiquitination[3]
295EASEENRKIDIQAKRubiquitination[4]
301RKIDIQAKRVQARLDubiquitination[3]
313RLDNLQRKYEFMTIQubiquitination[3]
323FMTIQRLKGSSHAVHubiquitination[3]
339MKSLKQEKAPVSKTYubiquitination[3]
388DGKKPQLKFASQRNDubiquitination[3, 5]
399QRNDIQEKCVKLLPLubiquitination[3]
458RLGEDIFKGVVTKGIubiquitination[3]
463IFKGVVTKGIQDNSPubiquitination[3, 6, 7]
477PQHSVENKPKTAAFFubiquitination[3, 5, 7]
479HSVENKPKTAAFFKSubiquitination[3]
485PKTAAFFKSSNLPLRubiquitination[3, 5]
526DLKTEEGKTLFLEYQubiquitination[6]
606KLSIILQKLSKIKSNubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 CROSSLNK 295 295 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Isopeptide bond; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 665 AA 
Protein Sequence
MEPRVVKPPG QDLVVESLKS RYGLGGSCPD EYDFSNFYQS KYKRRTLTSP GDLDIYSGDK 60
VGSSLKYSDE SKHCRTPLGS LFKHVNVNCL DDELDSFHDL KKQETEEELI ENDYRVSTSK 120
ITKQSFKEIE KVALPTNTTS SRPRTECCSD AGDSPLKPVS CPKSKASDKR SLLPHQISQI 180
YDELFQIHLK LQCETAAQQK FAEELQKRER FLLEREQLLF RHENALSKIK GVEEEVLTRF 240
QIIKEQHDAE VEHLTEVLKE KNKETKRLRS SFDALKELND TLKKQLNEAS EENRKIDIQA 300
KRVQARLDNL QRKYEFMTIQ RLKGSSHAVH EMKSLKQEKA PVSKTYKVPL NGQVYELLTV 360
FMDWISDHHL SKVKHEESGM DGKKPQLKFA SQRNDIQEKC VKLLPLMTEQ LQWMPFVNIK 420
LHEPFVKFIY WSLRQLDAGA QHSTMTSTLR RLGEDIFKGV VTKGIQDNSP QHSVENKPKT 480
AAFFKSSNLP LRFLSTLIVL KTVTQADYLA QAFDSLCLDL KTEEGKTLFL EYQAVPVILS 540
HLRISSKGLL SNVIDSLLQM TVESKSLQPF LEACSNSLFF RTCSVLLRAP KLDLQILEKL 600
SIILQKLSKI KSNKKLFELF TIHLMLQEIQ RTTNPEHAFL CINLNSTLFN LGLTKCNSLV 660
SSASP 665 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS