CPLM-018599

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018599

UniProt Accession

UIF_MOUSE; Q91Z49; Q3TJ68; Q3UT89; Q8BVM8; Q8K361; Q921B0; Q9D6A8

Genbank Protein ID

AK014447; AK029785; AK050448; AK050479; AK077184; AK139638; AK157602; AK161252; AK166032; AK167564; AK170511; BC010204; BC028253; AJ344096

Genbank Nucleotide ID

BAB29357.1; BAC26615.1; BAC34260.1; BAC34279.1; BAC36666.1; BAE24091.1; BAE34132.1; BAE36271.1; BAE38533.1; BAE39627.1; BAE41848.1; AAH10204.1; AAH28253.1; CAC51437.1

Protein Name

UAP56-interacting factor

Protein Synonyms/Alias

Forty-two-three domain-containing protein 1; Protein 40-2-3

Gene Name

Fyttd1

Gene Synonyms/Alias

Uif

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
81	QQNSGFGKTSLSRRG	ubiquitination	[1]
308	RANLTFSKGGSRFVT	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity).

Sequence Annotation

MOTIF 26 44 UAP56-binding motif.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 23 23 Phosphoserine.
CROSSLNK 139 139 Glycyl lysine isopeptide (Lys-Gly)

Keyword

Acetylation; Alternative splicing; Complete proteome; Isopeptide bond; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transport; Ubl conjugation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

317 AA

Protein Sequence

MNRFGTRLVG ATATPPPPPK ARSNENLDKI DMSLDDIIKL NRKEGKKQNF PRLNRRLQQS 60
GTRQFRMRVR WGIQQNSGFG KTSLSRRGRV LPGKRRPYGV ITGLAARKAT GIRKGISPMN 120
RPPLSDKNIE RYFPALKRKT SLLRQNEVQR KQVAVLKRPN QLNRKNNIPA NFTRNGNKLS 180
HQKDTRQATF LFRRGLKVQT QLNTEQLIDD VVAKRTRQWR TSTTNGGILT VSIDNPGAVQ 240
CPVTQKPRLT RTAVPSFLTK REQSDVKKVP KGVPLQFDIN SVGKQTGMTL NERFGILKEQ 300
RANLTFSKGG SRFVTVG 317

Gene Ontology

GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0003729; F:mRNA binding; ISS:UniProtKB.
GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.

Interpro

IPR009782; DUF1346.

Pfam

PF07078; FYTT

SMART

PROSITE

PRINTS