CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032918
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 AP-4 complex subunit mu-1 
Protein Synonyms/Alias
  
Gene Name
 AP4M1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110TEEFCVGKSELRGYGubiquitination[1, 2, 3]
196LRCDLLSKSQALNVRubiquitination[2, 3]
225ELSSPEQKAELAEGAubiquitination[1, 2, 4]
310CGNANPHKWVRHLSHubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MLRNFIQTEA VVSKPFSLFD LSSVGLFGAE TQQSKVAPSS AASRPVLSSR SDQSQKNEVF 60
LDVVERLSVL IASNGSLLKV DVQGEIRLKS FLPSGSEMRI GLTEEFCVGK SELRGYGPGI 120
RVDEVSFHSS VNLDEFESHR ILRLQPPQGE LTVMRYQLSD DLPSPLPFRL FPSVQWDRGS 180
GRLQVYLKLR CDLLSKSQAL NVRLHLPLPR GVVSLSQELS SPEQKAELAE GALRWDLPRV 240
QGGSQLSGLF QMDVPGPPGP PSHGLSTSAS PLGLGPASLS FELPRHTCSG LQVRFLRLAF 300
RPCGNANPHK WVRHLSHSDA YVIRI 325 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS. 
Pfam
 PF00928; Adap_comp_sub 
SMART
  
PROSITE
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 
PRINTS
 PR00314; CLATHRINADPT.