UniProt Accession

 Q6FIC5_HUMAN; Q6FIC5 

Genbank Protein ID

 AK315051; CR533501; CH471134 

Genbank Nucleotide ID

 BAG37528.1; CAG38532.1; EAW95143.1 

Protein Name

 CLIC4 protein 

Protein Synonyms/Alias

 Chloride intracellular channel 4, isoform CRA_b; cDNA, FLJ96000, Homo sapiens chloride intracellular channel 4 (CLIC4), mRNA 

Gene Name

 CLIC4 

Gene Synonyms/Alias

 hCG_24047 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	TTVDLKRKPADLQNL	ubiquitination	[1, 2]
106	LCPPKYLKLSPKHPE	ubiquitination	[1]
110	KYLKLSPKHPESNTA	ubiquitination	[1]
130	AKFSAYIKNSRPEAN	ubiquitination	[1, 2]
146	ALERGLLKTLQKLDE	ubiquitination	[1, 2]
177	DIKFSTRKFLDGNEM	ubiquitination	[1]
194	ADCNLLPKLHIVKVV	ubiquitination	[2]
199	LPKLHIVKVVAKKYR	ubiquitination	[1, 2]
212	YRNFDIPKEMTGIWR	ubiquitination	[1, 2]
249	IAYSDVAKRLTK***	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

  

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005773; C:vacuole; IEA:Compara.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0001886; P:endothelial cell morphogenesis; IEA:Compara.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Compara.
 GO:0007035; P:vacuolar acidification; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS

 PR01263; INTCLCHANNEL.