| Tag | Content |
|---|
| CPLM ID | CPLM-024152 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptic vesicle glycoprotein 2C |
Protein Synonyms/Alias | Synaptic vesicle protein 2C |
Gene Name | Sv2c |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 506 | NGRFLGVKFKSVTFK | acetylation | [1] | | 513 | KFKSVTFKDSVFKSC | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. |
Sequence Annotation | REGION 1 57 Interaction with SYT1.
REGION 529 566 BOTA-binding.
CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
CARBOHYD 484 484 N-linked (GlcNAc...) (Potential).
CARBOHYD 534 534 N-linked (GlcNAc...) (Potential).
CARBOHYD 559 559 N-linked (GlcNAc...) (Potential).
CARBOHYD 565 565 N-linked (GlcNAc...) (Potential). |
Keyword | Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Neurotransmitter transport; Receptor; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 727 AA |
Protein Sequence | MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEDDDDDYYP 60
PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN QGKDSIVSVG QPKGDEYKDR 120
RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE 180
TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG 240
YGFFLLCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI 300
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL 360
KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT 420
FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL SVWFPDVIKH LQSDEYALLT RNVQKDKYAN 480
FSINFTMENQ VHTGMEYDNG RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT 540
LFENTDFEPY KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS 600
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE 660
LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP ILLASTVLVC GGLVGLRLPD 720
TRTQVLM 727 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0008021; C:synaptic vesicle; IDA:RGD. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0022857; F:transmembrane transporter activity; IEA:InterPro. GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |