UniProt Accession

 NUDC2_HUMAN; Q8WVJ2; B2R4V0 

Genbank Protein ID

 FJ215684; AK311957; BX538290; CH471062; BC017934 

Genbank Nucleotide ID

 ACJ05660.1; BAG34897.1; CAD98085.1; EAW61527.1; AAH17934.1 

Protein Name

 NudC domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 NUDCD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	GREILKGKLFDSTIA	ubiquitination	[1]
121	VQDQMQRKLTLERFQ	ubiquitination	[1]
129	LTLERFQKENPGFDF	ubiquitination	[1, 2]
147	EISGNYTKGGPDFSN	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. 

Sequence Annotation

 DOMAIN 14 104 CS.
 MOD_RES 145 145 Phosphotyrosine (By similarity).  

Keyword

 Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IDA:LIFEdb.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF04969; CS 

SMART

  

PROSITE

 PS51203; CS 

PRINTS