UniProt Accession

 MAF_MOUSE; P54843; Q3V1Z2; Q4QY62 

Genbank Protein ID

 S74567; AY560005; AK132165; AC113301 

Genbank Nucleotide ID

 AAB32820.1; AAY81957.1; BAE21007.1 

Protein Name

 Transcription factor Maf 

Protein Synonyms/Alias

 Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog 

Gene Name

 Maf 

Gene Synonyms/Alias

 Maf2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
33	DLMKFEVKKEPVETD	sumoylation	[1]

Reference

 [1] SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.
 Leavenworth JW, Ma X, Mo YY, Pauza ME.
 J Immunol. 2009 Jul 15;183(2):1110-9. [PMID: 19553542] 

Functional Description

 Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)- mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf- responsive element binding. 

Sequence Annotation

 DOMAIN 285 348 bZIP.
 REGION 126 370 Represses ARE-mediated transcription (By
 REGION 285 310 Basic motif (By similarity).
 REGION 313 334 Leucine-zipper (By similarity).  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0048468; P:cell development; IMP:MGI.
 GO:0001816; P:cytokine production; IDA:MGI.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0070306; P:lens fiber cell differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0032330; P:regulation of chondrocyte differentiation; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR004826; bZIP_Maf.
 IPR008917; Euk_TF_DNA-bd.
 IPR013592; Maf_TF_N.
 IPR024874; Transciption_factor_Maf. 

Pfam

 PF03131; bZIP_Maf
 PF08383; Maf_N 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS