CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026828
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Rasgrp3 
Protein Synonyms/Alias
 RAS, guanyl releasing protein 3 
Gene Name
 Rasgrp3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
257HSSISRLKDTHSHLSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Guanine-nucleotide releasing factor; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 691 AA 
Protein Sequence
MGSNGLGKAA TLDELLSTCI EMFDDNGDLN DSYLPRIVLL MHRWYLSSTE LAGKLLCMYR 60
NASGESCDEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE EFREVASQLG HEKHISLMDI 120
SSVPSYDWMR RVTQRKKVSK RGKACLLFDH LEPIELAEHL TFLEHKSFRR ISFTDYQSYV 180
IHGCLENNPT LERSIALFNG ISKWVQLMVL SKPSAQQRAE VITKFINVAQ KLLQLKNFNT 240
LMAVVGGLSH SSISRLKDTH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP 300
ILGVHLKDLI AVHVIFPDWM EENKVNVVKM HQLSVTLSEL VSLQNASHHL EPNMDLINLL 360
TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV PLEWASEVVP KPDPTIINKH 420
IRKLVESVFR NYDHDHDGYI SQEDFESIAA NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR 480
AKSQLHCKMG PGFIHNFQEM NYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL 540
VLACRRLARA PSLSSNPGSL PGSPALPPVQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK 600
ISVRLQRATT SQATQTEPVW SEAVWGDSGS HTFPKMKSKF HDKAAKDKGF AKWENEKPTV 660
QAGVDVVDRG TAFEPDQDDG QDEAKQGGED G 691 
Gene Ontology
 GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0046582; F:Rap GTPase activator activity; IEA:Compara.
 GO:0017016; F:Ras GTPase binding; IDA:MGI.
 GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0007265; P:Ras protein signal transduction; IDA:MGI.
 GO:0043087; P:regulation of GTPase activity; IDA:MGI. 
Interpro
 IPR020454; DAG/PE-bd.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00130; C1_1
 PF13202; EF_hand_3
 PF13405; EF_hand_4
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00109; C1
 SM00054; EFh
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00008; DAGPEDOMAIN.