UniProt Accession

 ATAD1_HUMAN; Q8NBU5; D3DR26; Q6DKG1; Q6P4B9; Q8N3G1; Q8WYR9; Q969Y3 

Genbank Protein ID

 AF361493; AK027506; AK075223; AL133327; AC022016; CH471066; CH471066; CH471066; BC010868; BC063530; BC073998; AL834370 

Genbank Nucleotide ID

 AAL57218.1; BAB55161.1; BAC11482.1; CAI16701.1; CAI16701.1; EAW50180.1; EAW50177.1; EAW50179.1; AAH10868.1; AAH63530.1; AAH73998.1; CAD39033.1 

Protein Name

 ATPase family AAA domain-containing protein 1 

Protein Synonyms/Alias

 Thorase 

Gene Name

 ATAD1 

Gene Synonyms/Alias

 FNP001 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
165	QPSTLTDKWYGESQK	ubiquitination	[1]
263	HINQPALKQREAILK	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). 

Sequence Annotation

 NP_BIND 133 140 ATP (Potential).
 MOD_RES 322 322 Phosphoserine (By similarity).
 CROSSLNK 46 46 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; ATP-binding; Cell junction; Cell membrane; Complete proteome; Hydrolase; Isopeptide bond; Membrane; Nucleotide-binding; Peroxisome; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Synapse; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0007612; P:learning; ISS:UniProtKB.
 GO:0007613; P:memory; ISS:UniProtKB.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
 GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS