UniProt Accession

 IL4RA_HUMAN; P24394; B9EKU8; H3BSY5; Q96P01; Q9H181; Q9H182; Q9H183; Q9H184; Q9H185; Q9H186; Q9H187; Q9H188 

Genbank Protein ID

 X52425; AC004525; AF421855; AJ293647; AJ293648; AJ293649; AJ293650; AJ293651; AJ293652; AJ293653; AC106739; BC151131; AJ293654 

Genbank Nucleotide ID

 CAA36672.1; AAC23495.1; AAL12163.1; CAC20445.1; CAC20446.1; CAC20447.1; CAC20448.1; CAC20449.1; CAC20450.1; CAC20451.1; AAI51132.1; CAC20452.1 

Protein Name

 Interleukin-4 receptor subunit alpha 

Protein Synonyms/Alias

 IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; Soluble interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP 

Gene Name

 IL4R 

Gene Synonyms/Alias

 IL4RA; 582J2.1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
192	RIAASTLKSGISYRA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. 

Sequence Annotation

 DOMAIN 123 219 Fibronectin type-III.
 REGION 437 557 Required for IRS1 activation and IL4-
 REGION 558 657 Required for IL4-induced gene expression.
 MOTIF 212 216 WSXWS motif.
 MOTIF 262 270 Box 1 motif.
 MOTIF 711 716 ITIM motif.
 MOD_RES 497 497 Phosphotyrosine.
 MOD_RES 575 575 Phosphotyrosine (Probable).
 MOD_RES 603 603 Phosphotyrosine (Probable).
 MOD_RES 631 631 Phosphotyrosine (Probable).
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
 DISULFID 34 44 By similarity.
 DISULFID 74 86 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 825 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004913; F:interleukin-4 receptor activity; TAS:ProtInc.
 GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0045626; P:negative regulation of T-helper 1 cell differentiation; IEA:Compara.
 GO:0030728; P:ovulation; IEA:Compara.
 GO:0090197; P:positive regulation of chemokine secretion; IEA:Compara.
 GO:0043032; P:positive regulation of macrophage activation; IEA:Compara.
 GO:0045630; P:positive regulation of T-helper 2 cell differentiation; IEA:Compara.
 GO:0002532; P:production of molecular mediator involved in inflammatory response; IEA:InterPro.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR003531; Hempt_rcpt_S_F1_CS.
 IPR013783; Ig-like_fold.
 IPR015319; IL4Ra_N. 

Pfam

 PF09238; IL4Ra_N 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3
 PS01355; HEMATOPO_REC_S_F1 

PRINTS