| Tag | Content |
|---|
| CPLM ID | CPLM-018105 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tether containing UBX domain for GLUT4 |
Protein Synonyms/Alias | Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog |
Gene Name | Aspscr1 |
Gene Synonyms/Alias | Tug |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 370 | EEAPLVTKAFREAQM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Enhances VCP methylation catalyzed by METTL21D (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. |
Sequence Annotation | DOMAIN 382 458 UBX.
REGION 313 376 Interaction with GLUT4.
MOD_RES 496 496 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 550 AA |
Protein Sequence | MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPSEY DLKFQRTVLD 60
LSLQWRFANL PNNAKLEMVP VSRSREGPEN IVRIAFQLDD GSRLQDAFCS RQTLWELLSH 120
FAQTRERLQQ LGEKTPVCVY MRNEVTGRAA LQNTTLQSLG LTGGSATIRF VIKQCDTAGK 180
QESIAVRSKA PGSPVSSLSA DQASSSTLLP LNSGEFSRGD LNHEGDANTS GTGLEGGPKP 240
TDAQTKQSTS EPASAPFVPF SGGGQRLGGP SASLRPLTSP SANSSKSFSG PGGPSKPKKP 300
KPGEEPQQEP EPPVDRDPVV YHPDLEDLLQ PWPAEVPDEF FEVTVDDVRR RLAQLKSERK 360
RLEEAPLVTK AFREAQMKEK LERYPKVALR VLFPDRYILQ GFFRPSETVG DLRDFVRSHL 420
GNPELSFYLF IAPPKMVLDD HTLTLFQANL FPAALVHFGA EEPTGLYLEP GLLEHTVSPS 480
TADVLVARCM SRASGSPPLL PAPDPVSLES EPIAEDGALG PPEPIQGTAQ PVKRSLGKVP 540
KWLKLPASKR 550 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome. GO:0005829; C:cytosol; IDA:MGI. GO:0019898; C:extrinsic to membrane; IDA:MGI. GO:0009898; C:internal side of plasma membrane; IDA:MGI. GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. GO:0042593; P:glucose homeostasis; IDA:MGI. GO:0006886; P:intracellular protein transport; IDA:MGI. GO:0046324; P:regulation of glucose import; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |