UniProt Accession

 RAB5A_HUMAN; P20339; Q6FI44 

Genbank Protein ID

 M28215; AF464088; AF498936; AK312618; CR536492; CH471055; BC001267; BC018288 

Genbank Nucleotide ID

 AAA60245.1; AAO15677.1; AAM21084.1; BAG35504.1; CAG38731.1; EAW64301.1; AAH01267.1; AAH18288.1 

Protein Name

 Ras-related protein Rab-5A 

Protein Synonyms/Alias

  

Gene Name

 RAB5A 

Gene Synonyms/Alias

 RAB5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	LGESAVGKSSLVLRF	ubiquitination	[1]
116	ARAKNWVKELQRQAS	ubiquitination	[1, 2]
134	VIALSGNKADLANKR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. 

Sequence Annotation

 NP_BIND 27 35 GTP.
 NP_BIND 75 79 GTP.
 NP_BIND 133 136 GTP.
 NP_BIND 163 165 GTP.
 MOTIF 49 57 Effector region (By similarity).
 LIPID 212 212 S-geranylgeranyl cysteine.
 LIPID 213 213 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; Differentiation; Endosome; GTP-binding; Lipoprotein; Membrane; Neurogenesis; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:2000286; P:receptor internalization involved in canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.