| Tag | Content |
|---|
| CPLM ID | CPLM-010717 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger X-linked protein ZXDB |
Protein Synonyms/Alias | |
Gene Name | ZXDB |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 433 | CSFPGCSKQYDKACR | ubiquitination | [1] | | 493 | CPVEGCGKSFTRAEH | ubiquitination | [1] | | 537 | SLYIHSKKHLQDVDT | ubiquitination | [1] | | 561 | CNKLFTSKHSMKTHM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes (By similarity). |
Sequence Annotation | ZN_FING 271 295 C2H2-type 1.
ZN_FING 304 328 C2H2-type 2.
ZN_FING 334 358 C2H2-type 3.
ZN_FING 364 386 C2H2-type 4.
ZN_FING 393 417 C2H2-type 5.
ZN_FING 424 448 C2H2-type 6.
ZN_FING 454 478 C2H2-type 7.
ZN_FING 484 508 C2H2-type 8.
ZN_FING 514 538 C2H2-type 9.
ZN_FING 547 572 C2H2-type 10.
REGION 271 577 Required for interaction with ZXDC (By
REGION 576 703 Required for transcriptional activation |
Keyword | Activator; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 803 AA |
Protein Sequence | MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP QDGGPGRRRE 60
EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV GGDVETAGSG QAAGPVLREE 120
AEEGPGLQGG ESGANPAGPT ALGPRCLSAV PTPAPISAPG PAAAFAGTVT IHNQDLLLRF 180
ENGVLTLATP PPHAWEPGAA PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA 240
PAPAPEEEAE GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG 300
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN LKAHMKGHEQ 360
ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC KKTFITVSAL FSHNRAHFRE 420
QELFSCSFPG CSKQYDKACR LKIHLRSHTG ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD 480
DRRFMCPVEG CGKSFTRAEH LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ 540
DVDTWKSRCP ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN 600
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA NNNNSVGQAV 660
DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS VSVGPLGSLD SLAMKNSSPE 720
PQALTPSSKL TVDTDALTPS STLCENSVSE LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN 780
AAGNHGSQKE TDLITVTGSS FLV 803 |
Gene Ontology | GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |